Comparison of pathogen spectrums among children with respiratory tract infection between a primary and a grade-A tertiary children's hospital
Objective To compare the pathogen spectrums among children with acute respiratory tract infection between a primary and a grade-A tertiary children's hospital under hierarchical diagnosis and treatment.Methods From November 2021 to March 2022,children who visited either a primary hospital or a grade-A tertiary children's hospital and were diagnosed with acute respiratory tract infections were selected for respiratory tract pathogen screening using multiple RT-PCR and capillary electrophoresis.The spectrum of pathogen was compared between these hospitals using the statistical software SPSS 23.0.Results A total of 112 cases were enrolled from the primary hospital,with a male to female ratio of 1∶1.Out of these cases,71.43％ (80/112) were found to have respiratory pathogens.Among them,72 cases were infected by one pathogen (64.29％,72/112) and 8 cases were co-infected by two pathogens (7.14％,8/112).In this group,70.43％ (81/115) were found to have respiratory pathogens,Out of these cases,66 were infected by one pathogen (57.39％,66/115).12 cases were co-infected by two pathogens (10.43％,12/115),and 3 cases were infected by three pathogens (2.61％,3/115).In children aged 0-3 years,the positive rate of HMPV showed a significant dif-ference (x2=38.10,P<0.05) between the primary hospital (52.9％,9/17) and the grade-A tertiary children's hos-pital (5.3％,4/75).The positive rate of RSV was higher in the grade-A tertiary children's hospital (44.0％,33/75) compared to the primary hospital (23.5％,4/17),but showed no significant difference (x2=2.415,P>0.05).For children aged 4-15 years,significant differences were observed in the positive rate of Flu B (31.58％,30/95 in the primary hospital;20.0％,8/40 in the grade-A tertiary children's hospital) (x2=6.96,P<0.05) and MP (37.5％,15/40 in the grade-A tertiary children's hospital;zero in the primary hospital) (x2=40.08,P<0.05).Conclusion During the winter and spring of 2021-2022,the composition of pathogenic spectrum in acute respiratory tract in-fections in children varied between a primary and a grade-A tertiary children's hospital in Beijing.This difference was also observed across different age groups.These findings suggest the importance of implementing hierarchical diagnosis and treatment,as well as nucleic acid testing in primary hospitals.
万方数据
维普
