Analysis of the effect of magnesium valproate combined with donepezil in the treatment of senile dementia
Objective To analyze the changes of cognitive function and serum levels of neuro-trophic factor (BDNF),ceruloplasmin (CER) and microribonucleic acid-132 (miRNA-132) after magnesium valproate combined with donepezil treatment in elderly patients with dementia.Methods 110 cases of senile dementia patients were admitted to the Seventh People's Hospital of Hengshui City from October 2020 to Octo-ber 2022.They were randomly divided into an experimental group and a control group,with 55 cases in each group determined by the random number table method.The control group received donepezil hydrochloride tab-lets,while the test group received magnesium valproate tablets.The treatment course for both groups was 3 months.The study compared cognitive function,psychobehavioral symptoms,inflammatory factors,neurologi-cal function,and safety between the two groups.Results Compared to pre-treatment scores,the Brief Mon-treal Cognitive Assessment (MoCA),Mini-Mental State Examination (MMSE),BDNF,CER and miRNA-132 levels in both groups increased after 3 months of treatment.The levels in the test group were higher than those in the control group,with statistical significance (t=12.322,9.215,20.914,18.728 and 11.721,P<0.05).Similarly,compared to pre-treatment levels,the scores of the neuropsychiatric symptom questionnaire (NPI),interleukin-1 β (IL-1β),C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) levels in both groups decreased after 3 months of treatment.The test group had lower levels than the control group,with statis-tical significance (t=10.522,6.995,14.639,6.516,P<0.05).There were no statistical differences in safety be-tween the two groups during treatment (P>0.05).Conclusion Alzheimer's disease patients treated with magne-sium valproate combined with donepezil showed increased levels of BDNF,CER,and miRNA-132.They also experienced improved neurological function,reduced inflammation in the body,and further enhancement of cognitive function and neurobehavioral symptoms.Additionally,this treatment had a favorable safety profile.
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