Risk factors of pulmonary infection after thoracoscopic surgery for lung cancer and the value of serum Cit H3 and TREM-1 in early prediction of postoperative pulmonary infection
Objective To investigate the risk factors of lung infection after thoracoscopic surgery for lung cancer and the value of serum citrolinated histone H3 (Cit H3) and trigger receptor 1 (TREM-1) ex-pressed on myeloid cells in early prediction of lung infection.Methods From July 2020 to July 2023,89 pa-tients with lung cancer undergoing thoracoscopic surgery at the First People's Hospital of Mengcheng County,Anhui Province were selected.The incidence of postoperative lung infections was statistically analyzed,and the risk factors of lung infections were analyzed using logistic regression.The predictive value of serum Cit H3 and TREM-1 levels in pulmonary infection was analyzed using receiver operating characteristic (ROC) curves.Results A total of 18 out 89 patients with lung cancer who underwent thoracoscopic surgery had pulmonary in-fections,resulting in an incidence rate of 20.45% (18/88).Logistic regression analysis showed that age,smok-ing index,preoperative FEV1%,pathological stage,operation time and preoperative serum Cit H3 and TREM-1 levels were all influencing factors for lung cancer infection after thoracoscopic surgery (P<0.05).The ROC curve showed that Cit H3 and TREM-1 combined prediction of lung cancer thoracoscopic postoperative lung in-fection had the largest AUC value of 0.715,with a corresponding sensitivity of 0.814,and specificity of 0.828.Conclusion The rate of lung infection after thoracoscopic surgery is high.The combined detection of Cit H3 and TREM-1 is helpful in improving the diagnostic value of lung infection following thoracoscopic surgery.