Relationship of different subtypes of LDL and HDL with AIP index and syntax score in elderly patients with T2DM and coronary heart disease
Objective To explore the relationship between different subtypes of low-density lipo-protein (LDL) and high-density lipoprotein (HDL) and atherogenic index of plasma (AIP),syntax score in elderly patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease.Methods 158 elderly patients with T2DM and coronary heart disease were selected as the study group,and 50 elderly pa-tients with simple coronary heart disease were enrolled as the control group.All patients underwent coronary angiography.The levels of different subtypes of serum LDL and HDL and AIP index were detected.Based on the syntax score,the patients in the study group were divided into three groups:low score group (n=68),middle score group (n=54) and high score group (n=36).The relationship between different subtypes of LDL and HDL with the AIP index and syntax score in elderly T2DM patients with coronary heart disease was ana-lyzed.Results The large and light LDL,medium-density LDL,small and dense LDL,HDL3,AIP and syn-tax score in the study group were higher than those in the control group while HDL2 was lower than that in the control group (P<0.05).BMI and TG in the high score group were higher while the proportions of hyperten-sion,smoking and drinking were lower than those in the low score group and middle score group (P<0.05).The medium-density LDL,small and dense LDL,HDL3,AIP and syntax score in the high score group were significantly higher while HDL2 was significantly lower compared to the low score group and middle score group (P<0.05).Pearson correlation analysis revealed that medium-density LDL,small and dense LDL and HDL3 were positively correlated with AIP and syntax score (P<0.05),and HDL2 was negatively correlated with AIP and syntax score (P<0.05).Multivariate logistic regression analysis showed that body mass index (BMI),triglyceride (TG),medium-density LDL,small and dense LDL,HDL2 and HDL3 were independent influencing factors of syntax score>32 points in elderly T2DM patients with coronary heart disease (P<0.05).Conclusion The changes in different subtypes of LDL and HDL are significantly correlated with the AIP in-dex and syntax score in elderly patients with T2DM and coronary heart disease.The higher the levels of differ-ent subtypes of LDL and the lower the levels of HDL2,the more advanced the arteriosclerosis in patients with T2DM and coronary heart disease.
Type 2 diabetes mellitusCoronary heart diseaseLow density lipoproteinHigh density lipoproteinAtherogenic index of plasma
万方数据
维普
