Prognostic value of peripheral blood lymphocytes,LMR and IL-6 in sepsis
Objective To investigate the levels of lymphocyte,lymphocyte/monocyte (LMR) and interleukin-6 (IL-6) in peripheral blood of sepsis and their prognostic value.Methods The clinical data of 120 children with sepsis admitted to the Pediatric Infection Department of Suzhou Municipal Hospital in An-hui Province from January 2020 to December 2022 were retrospectively collected.They were divided into a mild group (76 cases) and a severe group (44 cases) based on their disease conditions.The levels of periph-eral blood lymphocytes,LMR and IL-6 were compared between the two groups.Based on a 10-day outcome,the patients with sepsis were further divided into a good prognosis group (79 cases) and a poor prognosis group (41 cases).The above serum indicators,blood routine[including white blood cell count (WBC),C-re-active protein (CRP),procalcitonin (PCT),tumor necrosis factor (TNF-α)]levels,acute physiological and chronic health status Ⅱ (APACHEⅡ) and childhood sequential organ failure (p-SOFA) scores were com-pared between the two groups.The prognostic factors of sepsis and the prognostic value of lymphocyte,LMR and IL-6 levels in peripheral blood were analyzed.Results The levels of peripheral blood lymphocytes and LMR in mild patients were higher than those in severe patients (t=7.033,4.828,P<0.05),and IL-6 was lower than in severe patients,with statistical significance (t=6.880,P<0.05).Peripheral blood lymphocytes and LMR in the good prognosis group were higher than in the poor prognosis group (t=6.915,5.932,P<0.05),APACHEⅡ,P-SOFA scores and IL-6,CRP,PCT,TNF-α levels were lower in the poor prognosis group,and the differences were statistically significant (5.552,7.893,6.778,17.540,14.868,12.296,P<0.05).Peripheral blood lymphocytes,LMR,IL-6,CRP,PCT,TNF-α,APACHEⅡ and P-SOFA were all indepen-dent influencing factors for poor prognosis (P<0.05).The combined predictive efficacy of peripheral blood lym-phocytes,LMR and IL-6 was higher than that of single detection (AUC=0.957,P<0.05).Conclusion The ab-normal expression of peripheral blood lymphocytes,LMR and IL-6 in children with sepsis are all adverse prog-nostic factors.The combined prediction of these three factors has important prognostic value for sepsis.
Peripheral blood lymphocytesLymphocyte to monocyte ratioInterleukin-6SepsisPrognosis
万方数据
维普
