Relationship between CRP/PAB ratio and severity or onset in patients with primary knee osteoarthritis
Objective To explore the relationship between the C-reactive protein/prealbumin (CRP/PAB) ratio and the severity and onset of the disease in patients with primary knee osteoarthritis (KOA).Methods 93 patients with primary KOA admitted to Hainan Western Central Hospital from February 2021 to January 2023 were selected as the subjects of this study (KOA group).According to the Kellgren Lawrence (KL) classification,the patients were divided into a mild to moderate group of 66 cases (KL grading 1-3) and a severe group of 27 cases (KL grading 4).In addition,130 healthy individuals who came to our hospital for physical examinations during the same period were selected as the control group.The study aimed to compare the serum CRP,PAB levels,and CRP/PAB ratio between the KOA group and the control group,as well as between the mild to moderate group and the severe group.The predictive value of CRP,PAB,and the CRP/PAB ratio on the condition of primary KOA patients was evaluated using receiver operating characteristic (ROC) curves.The influencing factors of primary KOA patients were identified using binary logistic stepwise regression analysis.Results The serum CRP level and the CRP/PAB ratio in the KOA group were higher than those in the control group,while the PAB level was lower than that in the control group,with statistical sig-nificance (P<0.05).The serum CRP level and the CRP/PAB ratio in the severe group were higher than those in the mild to moderate group,and the PAB level was lower than that in the mild to moderate group,with statisti-cal significance (P<0.05).The area under the curve (AUC) of CRP,PAB and CRP/PAB ratio in predicting the disease condition of patients with primary KOA were 0.849 (0.797~0.901),0.751 (0.699~0.803) and 0.903 (0.851~0.955),respectively.Cut-off values were 52.55 mg/L,172.77 mg/L and 0.37,the specificity was 0.680,0.571 and 0.870,and the sensitivity was 0.913,0.913 and 0.845,respectively.Old age (OR=2.368,95%CI:1.584~3.539),family history of KOA (OR=2.158,95%CI:1.475~3.156),CRP/PAB ratio was ≥0.37(OR=2.782,95%CI:1.797~4.306) were independent risk factors for primary KOA patients (P<0.05).Conclusion The increase in the CRP/PAB ratio in serum is closely related to the onset and severity of primary KOA.This ratio can be used as a potential biomarker to predict the disease in primary KOA patients and has certain clinical application value.