Efficacy of glimepiride combined with Dagliagrazin in the treatment of type 2 diabetic nephropathy and its effect on BUN,CREA and ACR levels
Objective To explore the efficacy of glimepiride combined with dagliprazin in the treatment of type 2 diabetic nephropathy and the effects on the levels of urea nitrogen (BUN),creatinine (CREA) and urinary albumin/creatinine ratio (ACR).Methods 120 patients with type 2 diabetic nephropa-thy who were admitted to the Endocrinology Department of Linquan County People's Hospital from March 2021 to Manch 2023 were selected as the study subjects.They were divided into two groups based on different treatment methods:64 cases received dagliaglizin treatment,while 56 cases received glimepiride combined with dagliprazin treatment.The treatment duration was 12 weeks.The differences in clinical efficacy,blood glucose standard time and daily insulin dosage between the two groups were compared,and the blood glucose indexes,BUN,CREA and ACR levels before and after treatment were compared between the dagliaglizin treatment group and the glimepiride combined with dagliprazin treatment group.Results The total effective rate of glimepiride combined with dagliprazin group was 96.43％,which was significantly higher than that of dagliprazin group (82.81％),the difference was statistically significant (x2=2.006,P<0.05).After 12 weeks of treatment,compared with dagliagrazin treatment group,the blood glucose standard time of glimepiplus combined with dagliagin treatment group was significantly shortened,and the daily insulin dosage was also sig-nificantly reduced,with statistical significance (t=4.449,9.958,P<0.05).The levels of FPG,HbA1c,BUN,CREA,and ACR in both groups were decreased,and the levels of FPG,HbA1c,BUN,CREA,and ACR in glimepiplus combined with dagliagin group were lower than those in Dagliagin group,with statistical significance (t=4.382,4.028,20.741,2.930,2.360,P<0.05).Conclusion Compared to using daaglizin alone,the combination of glimepiride and dagliprazin can effectively enhance blood glucose control,regulate insulin resistance,and reduce BUN,CREA and ACR levels in patients with type 2 diabetic nephropathy.
GlimepirideDagliprazinDiabetic nephropathyUrea nitrogenCreatinineUrinary albumin/creatinine ratio
万方数据
维普
