Expression of MRPS23 in breast cancer and its clinical relevance
Objective To investigate the correlation between the expression of MRPS23 in breast cancer tissues and clinical indexes.Methods A total of 30 patients with breast cancer who received treatment at Zhangzhou Affiliated Hospital of Fujian Medical University from June 2022 to June 2023 were selected.HE staining was used to observe the pathological changes in breast cancer tissues.The expression of MRPS23 in cancer and adjacent tissues was detected using immunohistochemistry.The correlation between MRPS23 ex-pression levels and survival time was analyzed using the GEPIA database.Results The HE results showed that tumor cells in the breast cancer tissue were arranged in nests,with large tumor nuclei,an increased nucleo-plasma ratio,and more lymphocyte and plasma cell infiltration in the stroma.The expression level of MRPS23 in cancer tissues was significantly higher than in adjacent tissues,and the difference was statistically significant (F=58.525,P<0.05).There was also a statistically significant difference in tumor size and Ki67 expression be-tween high and low levels of MRPS23 (t=-3.247,-2.574,P<0.05).MRPS23 expression in breast cancer,cervical cancer,glioma and other cancer tissues was higher than in adjacent tissues,with a statistically signifi-cant difference (P<0.05).The ROC curve AUC for breast cancer was as high as 0.9144(95％CI:0.8470～0.9819),and the survival curve showed that highly expressed MRPS23 was associated with a shorter survival period.Conclusion MRPS23 may serve as a potential marker for the treatment of breast cancer.
万方数据
维普
