Correlation of serum ChE,CysC,NLR with severity and prognosis of acute cerebral infarction
Objective To explore the correlation between serum cholinesterase (ChE),cystatin C (CysC),neutrophil to lymphocyte ratio (NLR) and the severity and prognosis of acute cerebral infarction (ACI) patients.Methods Data from 105 ACI patients admitted to the Eighth People's Hospital of Hefei from January 2018 to July 2023 were retrospectively analyzed.The patients were grouped based on their National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) scores after 6 months of follow-up post-discharge.Differences in baseline data and serum related indicators were compared among the groups.The relationship between serum ChE,CysC,NLR,NIHSS,and mRS scores,and the predictive value of serum ChE,CysC,and NLR on the prognosis of ACI patients,were analyzed.Results The proportion of patients with diabetes mellitus,hyperlipidemia,older age,higher NIHSS score at admission,and elevated serum CysC and NLR levels in the poor prognosis group were all significantly higher compared to those in the good prognosis group (x2=8.653,12.083,t=4.832,8.364,5.350,6.512,P<0.05).Converely,the level of ChE in serum was lower in the poor prognosis group than in the good prognosis group (t=5.651,P<0.05).The levels of ChE and CysC and NLR in serum decreased progressively as the disease worsened with statistically significant differences observed (F=19.203,6.755,20.154,P<0.05).Serum levels of ChE,CysC,and NLR were found to be correlated with both NIHSS score at admission and mRS score at 6 months of follow-up (r=-0.623,-0.551,0.526,0.581,0.613,0.649,P<0.05).ROC curve results showed that the area under the curve (AUC) for ChE,CysC and NLR individually were 0.861,0.777 and 0.824,respectively.When combined,the AUC of the detection was 0.940.Conclusion The levels of ChE,CysC,and NLR in the serum of ACI patients have a strong correlation with their disease and prognosis.Patients with lower levels of ChE,higher levels of CysC,and NLR tend to have more severe disease.The combined detection of these three markers has a high predictive value for the prognosis of ACI patients.
Acute cerebral infarctionSerum cholinesteraseCystatin CNeutrophil to lymphocyte ratio
万方数据
维普
