Analysis of serum miR-155,IL-17 and myocardial enzyme profile and prognosis in patients with acute myocardial infarction
Objective To analyze the correlation between serum microRNA-155 (miR-155) and interleukin-17 (IL-17) and myocardial enzyme profile and prognosis in patients with acute myocardial infarc-tion.Methods Patients with acute myocardial infarction (AMI) admitted to the North Anhui Coal Power Group General Hospital from January 2021 to April 2022 were selected as the research subjects and referred to as the AMI group (n=129).Healthy individuals who underwent physical examinations at our hospital during the same period were selected as the control group (n=80).Serum miR-155,IL-17 and myocardial enzyme profiles[creatine kinase (CK),creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH)]were compared between the two groups.Pearson correlation coefficient was used to analyze the correlation between serum miR-155,IL-17 and myocardial enzyme profiles in AMI patients.The patients were followed up for 1 year after the treatment,and the occurrence of cardiogenic shock,heart failure,recurrent myocardial infarction and death of patients during the follow-up period was considered as poor prognosis.The influencing factors of poor prognosis of AMI patients were analyzed according to multiple logistic regression.An ROC curve was drawn to analyze the predictive value of serum miR-155 and IL-17 levels for poor prognosis in AMI patients.Results The levels of serum miR-155,IL-17,CK,CK-MB and LDH in the AMI group were higher than those in the control group,with statistical significance (t=28.233,P<0.05).Pearson correlation analysis showed that serum miR-155 and IL-17 in AMI patients were positively correlated with CK,CK-MB and LDH (P<0.05).Multivariate logistic regression analysis showed that Age>60 years old (OR=2.083),history of hy-pertension (OR=1.687),history of diabetes (OR=1.740),high expression of miR-155 (OR=2.312),elevated IL-17 (OR=1.966),elevated CK (OR=2.098),elevated CK-MB (OR=2.067) and elevated LDH level (OR=2.300) were independent risk factors for poor prognosis in AMI patients (P<0.05).ROC curve analysis showed that the level of serum miR-155 and IL-17 and the area under the curve (AUC) of combined detection were 0.930,0.865 and 0.964,respectively,and combined detection was superior to single detection (P<0.05).Conclusion Serum levels of miR-155 and IL-17 are highly expressed in patients with acute myocardial infarc-tion,showing a close correlation with myocardial enzyme profile and prognosis.Therefore,miR-155 and IL-17 could serve as auxiliary predictors of a poor prognosis in patients with acute myocardial infarction.
万方数据
维普
