Effects of Q-tuned 1064 nm laser-assisted therapy on skin lesions and levels of LH,VEGF and COX-2 in patients with melasma
Objective To investigate the effects of Q-tuned 1064 nm laser-assisted therapy on skin lesions and levels of luteinising hormone (LH),vascular endothelial growth factor (VEGF) and cyclo-oxygenase-2 (COX-2) in patients with melasma.Methods 126 patients with chloasma who were treated in the outpatient clinic of the Department of Dermatology and Cosmetology at Jieshou Hospital of Traditional Chi-nese Medicine from July 2021 to June 2023 were selected.114 patients with chloasma met the clusion and ex-culusion criteria and were included in the restrospective analysis.The patients were divided into two groups based on treatment methods:the control group (n=55,receiving conventional drug therapy) and the observa-tion group (n=59,receiving conventional drug therapy+Q1064 nm laser modulation).Skin lesions,levels of LH,VEGF and COX-2,clinical efficacy,and incidence of complications were compared between the two groups.Results After treatment,the total MASI score of the observation group was lower than that of the control group,and the difference was statistically significant (P<0.05).The lesion area score and lesion color score of the observation group were also lower than those of the control group,and the difference was statisti-cally significant (P<0.05).Additionally,the LH and COX-2 levels of the observation group were lower than those of the control group,while the VEGF level was higher.These differences were statistically significant (P<0.05).The total effective rate of clinical efficacy in the observation group (91.52％) was higher than that in the control group (76.36％),and the difference was statistically significant (P<0.05).There was no signifi-cant difference in complications between the two groups (P>0.05).Conclusion Q-tuned nm laser assisted therapy can effectively reduce the levels of LH and COX-2 in patients with melasma,increase the levels of VEGF,reduce oxidative stress damage in the skin lesions,and significantly improve the skin lesions in pa-tients with high safety
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