摘要
目的 分析NCPAP与HHHFNC支持对NRDS患儿凝血功能、血气指标及氧化应激指标的影响.方法 选取2020年10月至2023年3月蚌埠医学院第二附属医院收治的102例NRDS患儿作为研究对象,均进行无创通气治疗,根据不同的通气方法分为NCPAP组(n=51)与HHHFNC组(n=51).比较两组的呼吸支持治疗相关指标、治疗失败率(72 h内气管插管率)、PS使用率以及并发症发生情况;比较两组治疗前后的凝血功能(TT、PT、APTT、D-D)、血气指标(PaCO2、PaO2、SaO2、LAC)及氧化应激指标(SOD、GSH-PX、MDA.结果 两组无创辅助通气时间、总用氧时间、住院时间、治疗失败率及PS使用率比较差异无统计学意义(t=0.682、1.141、1.099;x2=0.102、0.102,均P>0.05);两组严重呼吸暂停、支气管肺发育不良、颅内出血、坏死性小肠结肠炎、气漏及动脉导管未闭发生率比较无统计学意义(x2=0.000、0.000、0.000、0.136、0.000、0.088,均P>0.05);HHHFNC组的鼻损伤发生率低于NCPAP组,差异具有统计学意义(x2=3.991,P<0.05);两组治疗后的TT、PT、APTT、D-D、PaCO2、PaO2、SaO2、LAC、SOD、GSH-PX及MDA比较差异无统计学意义(t=0.683、0.928、0.780、0.733、1.119、1.345、1.254、0.408、0.544、1.643、1.046,均P>0.05).结论 NCPAP与HHHFNC治疗NRDS的疗效相当,均能够有效改善患儿凝血功能、血气指标及氧化应激,但HHHFNC的安全性更优.
Abstract
Objective To analyze the effects of NCPAP and HHHFNC on coagulation function,blood gas index and oxidative stress index of NRDS.Methods A total of 102 children with NRDS treated at the Second People's Hospital Affiliated to Bengbu Medical College from October 2020 to March 2023 were se-lected as the study subjects.All of them were treated with non-invasive ventilation and were divided into the NCPAP group (n=51) and the HHHFNC group (n=51) based on the different ventilation methods.The re-lated indexes of respiratory support therapy,treatment failure rate (tracheal intubation rate within 72 h),utili-zation rate of PS and complications were compared between the two groups.The coagulation function (TT,PT,APTT,D-D),blood gas index (PaCO2,PaO2,SaO2,LAC) and oxidative stress index (SOD,GSH-PX,MDA).Results There were no significant differences in the duration of non-invasive assisted ventila-tion,total oxygen consumption,hospital stay,treatment failure rate and PS utilization rate between the two groups (t=0.682,1.141,1.099;x2=0.102,0.102,P>0.05).There was no significant difference in the inci-dence of severe apnea,bronchopulmonary dysplasia,intracranial hemorrhage,necrotizing enterocolitis,air leakage and patent ductus arteriosus between the two groups (x2=0.000,0.000,0.000,0.136,0.000,0.088,P>0.05).The incidence of nasal injury in the HHHFNC group was significantly lower than that in the NCPAP group (x2=3.991,P<0.05).There was no significant difference in TT,PT,APTT,D-D,PaCO2,PaO2,SaO2,LAC,SOD,GSH-PX,and MDA between the two groups after treatment (t=0.683,0.928,0.780,0.733,1.119,1.345,1.254,0.408,0.544,1.643,1.046,P>0.05).Conclusion NCPAP and HHHFNC have similar efficacy in the treatment of NRDS.Both methods effectively improve coagulation function,blood gas index and oxidative stress in children.However,HHHFNC is safer.
基金项目
安徽省高等学校自然科学研究项目(KJ2021A0800)
维普
万方数据