Effects of two types of respiratory support on coagulation function,blood gas index and oxidative stress index in children with NRDS
Objective To analyze the effects of NCPAP and HHHFNC on coagulation function,blood gas index and oxidative stress index of NRDS.Methods A total of 102 children with NRDS treated at the Second People's Hospital Affiliated to Bengbu Medical College from October 2020 to March 2023 were se-lected as the study subjects.All of them were treated with non-invasive ventilation and were divided into the NCPAP group (n=51) and the HHHFNC group (n=51) based on the different ventilation methods.The re-lated indexes of respiratory support therapy,treatment failure rate (tracheal intubation rate within 72 h),utili-zation rate of PS and complications were compared between the two groups.The coagulation function (TT,PT,APTT,D-D),blood gas index (PaCO2,PaO2,SaO2,LAC) and oxidative stress index (SOD,GSH-PX,MDA).Results There were no significant differences in the duration of non-invasive assisted ventila-tion,total oxygen consumption,hospital stay,treatment failure rate and PS utilization rate between the two groups (t=0.682,1.141,1.099;x2=0.102,0.102,P>0.05).There was no significant difference in the inci-dence of severe apnea,bronchopulmonary dysplasia,intracranial hemorrhage,necrotizing enterocolitis,air leakage and patent ductus arteriosus between the two groups (x2=0.000,0.000,0.000,0.136,0.000,0.088,P>0.05).The incidence of nasal injury in the HHHFNC group was significantly lower than that in the NCPAP group (x2=3.991,P<0.05).There was no significant difference in TT,PT,APTT,D-D,PaCO2,PaO2,SaO2,LAC,SOD,GSH-PX,and MDA between the two groups after treatment (t=0.683,0.928,0.780,0.733,1.119,1.345,1.254,0.408,0.544,1.643,1.046,P>0.05).Conclusion NCPAP and HHHFNC have similar efficacy in the treatment of NRDS.Both methods effectively improve coagulation function,blood gas index and oxidative stress in children.However,HHHFNC is safer.
万方数据
维普
