Occurrence of hypothyroidism and its relationship with serum TGAb and TPOAb in patients with Graves' disease after 131I treatment
Objective To explore the occurrence of hypothyroidism and its relationship with anti-thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in patients with Graves' disease (GD) after 131I treatment.Methods The clinical data were collected from 72 patients with GD who underwent 131I treatment at Jingyan County People's Hospital between January 2021 and January 2023.According to pres-ence or absence of TGAb and TPOAb positive before treatment (either ≥60 U/mL:antibody positive),pa-tients were divided into a positive group(n=42) and a negative group (n=30).The general data,serum in-dexes and incidence of hypothyroidism were compared between the two groups.The correlation between serum TGAb,TPOAb levels and hypothyroidism in GD patients after 131I treatment was analyzed by logistic regres-sion analysis.Results Before and after treatment,levels of TGAb and TPAOb in the positive group were higher than those in the negative group,and the difference was statistically significant (P<0.05).After treat-ment,levels of TGAb and TPAOb increased in the negative group,the difference was statistically significant (P<0.05).The incidence of hypothyroidism in the positive group was higher than that in the negative group (40.28％ vs 16.67％),the difference was statistically significant (P<0.05).Multivariate logistic analysis showed that serum TGAb ≥ 60 U/mL and TPOAb ≥ 60 U/mL after 131I treatment were independent risk factors for hypothyroidism (P<0.05).Conclusion The detection of antibodies,serum TGAb and serum TPOAb is of great significance in GD patients.The three indexes can be applied as early assessment markers for the risk of hypothyroidism and can help guide the development of clinical treatment regimens for GD patients.
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