Application of closed negative pressure drainage and its effect on IL-6,5-HT,NPY levels in patients with oral and maxillofacial space infection
Objective To explore the application of closed negative pressure drainage and its ef-fect on IL-6,5-HT,NPY levels in patients with oral and maxillofacial space infection.Methods We retro-spectively analyzed 121 patients with oral and maxillofacial gap infections who were admitted to Handan Sto-matological Hospital during the period of March 2019-July 2023 and divided them into the control group (with incisional drainage,n=60 cases) and the observation group (with VSD,n=61 cases) according to the differ-ences in drainage methods.The two groups were compared in terms of clinical efficacy,treatment,interleukin 6 (IL-6),5-hydroxytryptamine (5-HT),neuropeptide Y (NPY) levels,pain level and postoperative infections.Results The total effective rate of the observation group (98.36％) was significantly higher than that of the control group (88.33％),the difference was statistically significant (P<0.05).The postoperative scar length and hospital stay of the observation group were shorter than that of the control group,and the relief value of the mouth opening restriction was higher than that of the control group,the difference was statistically signifi-cant (P<0.05).After treatment,the levels of IL-6,5-HT,NPY,and VAS scores of botj groups were re-duced,awith lower levels in the observation group.The difference was statistically significant (P<0.05).Com-paring the total incidence of postoperative infection between the two groups,the difference was not statistically significant (P>0.05).Conclusion The clinical efficacy of applying VSD to treat patients with oral and maxil-lofacial gap infections is high.This treatment can effectively improve the inflammatory response,reduce pain levels and enhance aesthetics.Therefore,it is worthy of clinical promotion and application.
Closed negative pressure drainageIncisional drainageOral and maxillofacial gap infectionIL-65-HTNPYAesthetics
万方数据
维普
