Relationship between serum Mb,GDF-15,ADAM9 and acute myocardial infarction,cardiogenic death in patients under 35 years old
Objective To investigate the relationship between serum myoglobin (Mb),growth differentiation factor-15 (GDF-15),a distegrinin and a metalloprotease 9 (ADAM9) and acute myocardial in-farction (AMI),cardiogenic death in patients under 35 years old.Methods A total of 115 patients with AMI admitted to Inner Mongolia People's Hospital from January 2016 to January 2023 were selected.According to the presence or absence of cardiogenic death during observation period (6 months of follow-up),they were di-vided into a death group and a survival group.Meanwhile,60 healthy individuals were chosen as the control group.Clinical data and serum Mb,GDF-15 and ADAM9 levels at admission were compared between the death group and the survival group.Logistic regression equation was used to screen the influencing factors for cardiogenic death in patients with AMI under 35 years old.The predictive value of serum Mb,GDF-15,ADAM9,and their combination for cardiogenic death in patients with AMI under 35 years old was evaluated using receiver operating characteristic (ROC) curves.Results Serum Mb,GDF-15 and ADAM9 levels in the AMI group were significantly higher than those in the control group,and the differences were statistically sig-nificant (P<0.05).In the AMI group,cardiogenic death occurred in 30 cases during the observation period,with an incidence rate of 26.07％.The proportion of patients with hypertension and serum Mb,GDF-15 and ADAM9 levels in the death group were significantly higher than those in the survival group,and the differ-ences were statistically significant (P<0.05).Logistic regression analysis showed that elevated serum Mb,GDF-15 and ADAM9 levels were risk factors for cardiogenic death in patients with AMI under 35 years old (P<0.05).Serum Mb,GDF-15 and ADAM9 were positively correlated in patients with AMI under 35 years old (P<0.05).The AUC of serum Mb combined with GDF-15 and ADAM9 for predicting cardiogenic death in patients with AMI under 35 years old was 0.877,which was greater than that of prediction using a single indi-cator (0.752,0.762,0.720,P<0.05).Conclusion Serum Mb,GDF-15 and ADAM9 levels are significantly increased in patients with AMI under 35 years old who have experienced an acute myocardial.The combined detection of the three indicators shows good predictive value for cardiogenic death in patients with AMI under 35 years old within 6 months.
Acute myocardial infarctionCardiogenic deathMyoglobinGrowth differentiation factor-15A distegrinin and a metalloprotease 9
万方数据
维普
