Effect of radical hysterectomy combined with pelvic lymph node dissection on serum CA-199,CA125,and SCC-Ag levels in patients with cervical cancer
Objective To investigate the effect of radical hysterectomy combined with pelvic lymph node dissection and the effects on the levels of serum tumor markers[carbohydrate antigen 199 (CA199),carbohydrate antigen 125 (CA125),squamous cell carcinoma antigen (SCC-Ag)]in patients with cervical cancer.Methods Data from 118 patients with cervical cancer who underwent surgical treatment at the Second People's Hospital of Wuhu City from January 2018 to June 2023 were retrospectively analyzed.The patients were divided into two groups based on their surgical plan,42 patients were classified into the tradi-tional laparotomy group and underwent traditional radical hysterectomy,while 76 cases were included in the minimally invasive group and underwent laparoscopic radical hysterectomy combined with pelvic lymph node dissection.The surgical outcomes and serum tumor markers were compared between the two groups.Results The operation time for the minimally invasive group was longer than that of the traditional laparotomy group,but the amount of intraoperative blood loss was less.The hospital stay and gastrointestinal recovery time were shorter than that of the traditional laparotomy group,the differences were statistically significant (t=6.881,12.348,21.622,11.780,P<0.05).Compared with pre-operation levels,the serum CA-199,CA125,and SCC-Ag levels in both groups decreased after surgery:before surgery>2 weeks after surgery>1 month after surgery.Furthermore,the levels of these indices in the minimally invasive group were condidtently lower than those in the laparotomy group at all time points after surgery (F=237.516,8.733,6.182,251.616,12.520,7.069,250.512,14.554,4.663,P<0.05).The total incidence of postoperative complications in the minimally invasive group was lower than that in the traditional laparotomy group,and the difference was statistically sig-nificant (x2=4.116,P<0.05).Conclusion Laparoscopic radical hysterectomy,combined with pelvic lymph node dissection in the treatment of cervical cancer,can optimize surgical outcomes,promote postoperative re-habilitation,enhance safety and improve prognosis.
万方数据
维普
