Evaluation value of peripheral blood PTH and CRP for prognosis of patients with ischemic stroke
Objective To explore the evaluation value of peripheral blood parathyroid hormone (PTH) and C-reactive protein (CRP) for prognosis of patients with ischemic stroke.Methods A total of 116 patients with ischemic stroke were enrolled as research subjects between June 2018 and December 2021.Based on different sizes of cerebral infarction,they were divided into a lacunar infarction group (49 cases),a small infarction group (44 cases) and a large infarction group (23 cases).The levels of peripheral blood PTH and CRP in patients with different degrees of infarction were compared,and the correlation with infarction size was analyzed.According to scores of modified Rankin Scale (mRS) at 3 months after onset,the patients were fur-ther divided into a good prognosis group (≤2 points) and a poor prognosis group (>2 points).The predictive value of peripheral blood PTH and CRP for prognosis and their relationship with poor prognosis were analyzed.Results The PTH and CRP levels revealed a pattern of large infarction group>small infarction group>lacunar infarction group (P<0.05).Peripheral blood levels of PTH and CRP were positively correlated with infarction size in patients with ischemic stroke (P<0.05).The levels of peripheral blood PTH and CRP in the poor progno-sis group were higher than those in the good prognosis group (P<0.05).The AUC of peripheral blood PTH combined with CRP for predicting prognosis was greater than that of PTH alone (P<0.05).PTH ≥ 12.82 ng/L and CRP ≥ 8.16 mg/L were indicative of a poor prognosis in patients with ischemic stroke (P<0.05).Conclusion The levels of peripheral blood PTH and CRP are correlated with the size of infarction in patients with ischemic stroke.The combined detection of the two indicators has evaluative value for the prognosis of patients.
万方数据
维普
