Effects of ziprasidone and risperidone in the treatment of schizophrenia on patients'cognitive function and serum GABA,INH,and Ach levels
Objective To analyze the changes in cognitive function,γ-aminobutyric acid (GABA),inhibin (INH),and acetylcholine (Ach) in patients with schizophrenia after applying ziprasidone and risperidone treatment.Methods A randomized numerical table method was used to divide 100 patients with schizophrenia selected from the psychiatric department of the Fifth Hospital of Tangshan City,Hebei Province,from June 2020 to June 2023 into a test and a control group of 50 cases each.The test and control groups were orally administered ziprasidone hydrochloride tablets and risperidone tablets,respectively,for a period of 2 months.Compare the efficacy (2 months after treatment),psychiatric symptom scores,cognitive function,neurotransmitter levels (before treatment and 2 months after treatment),and safety (during treat-ment) between two groups.Results After 2 months of treatment,the total effective rate of the experimental group was 92.00％,which was higher than 76.00％ of the control group,and the difference was statistically significant (x2=4.762,P<0.05).Comparison between the two groups after 2 months of treatment and before treatment,the positive,negative,psychopathological symptom scores,total scores,and serum INH and Ach levels were lower,and were lower in the experimental group compared to the control group,and the difference was statistically significant (t=9.449,5.243,20.206,17.310,15.229,7.345,P<0.05).Comparison between the two groups after 2 months of treatment and before treatment,the immediate,delayed,visual,delayed vi-sual memory scores,total scores,and serum GABA levels were higher,and were higer in the experimental group compared to the control group,with statistically significant differences (t=10.657,4.413,3.655,6.451,25.120,11.356,P<0.05).During the treatment period,the incidence of adverse reactions in the experi-mental group was 5.00％,lower than the control group's 26.00％ (x2=4.336,P<0.05).Conclusion Com-pared with risperidone,ziprasidone could significantly increase the serum GABA level in patients with schizo-phrenia,reduce serum INH and Ach levels,improve neurological,mental symptoms and cognitive function of patients,and improving efficacy,the safety of the two are equivalent.
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