Expression Levels of miR-34a-5p and miR-17-5p in Patients with Idiopathic Dilated Cardiomyopathy and Their Relationship with Heart Failure
Objective To explore the expression levels of miR-34a-5p and miR-17-5p and their re-lationship with heart failure in patients with idiopathic dilated cardiomyopathy (IDCM).Methods A total of 136 patients with IDCM were enrolled in the IDCM group between January 2019 and January 2023 in Youxian District Traditional Chinese Medicine Hospital and Sichuan Provincial People's Hospital,Mianyang.Based on presence or absence of heart failure,they were divided into a heart failure group (40 cases) and a non-failure group (96 cases).A total of 68 healthy volunteers without heart disease during the same period were enrolled as control group.The expression levels of miR-34a-5p and miR-17-5p,N-terminal pro brain natriuretic peptide(NT-proBNP),hypersensitive troponin T (hs-TnT),left ventricular ejection fraction (LVEF) and left ven-tricular end-diastolic inner diameter (LVEDD) were compared between the IDCM group and the control group,and between the heart failure group and the non-failure group.The correlation between serum miR-34a-5p,miR-17-5p and cardiac function indexes was also analyzed.The predictive value of miR-34a-5p and miR-17-5p for heart failure was analyzed using ROC curves.Results The levels of serum miR-34a-5p and miR-17-5p in the IDCM group were higher than those in the control group (P<0.05),the levels of serum NT-proBNP and hs-TnT were higher than those in the control group (P<0.05).The LVEF was lower in the IDCM group than in the control group (P<0.05),and the LVEDD was higher than that in the control group (P<0.05).The ex-pression levels of serum miR-34a-5p and miR-17-5p in the heart failure group were higher than those in the non-failure group (P<0.05).Similarly,the level of serum NT-proBNP was higher than that in the non-failure group (P<0.05).The LVEF was lower in the heart failure group than in the non-failure group (P<0.05),and the LVEDD was higher than that in the non-failure group (P<0.05).The expression levels of serum miR-34a-5p and miR-17-5p were positively correlated with the level of serum NT-proBNP (r=0.498,r=0.306,P<0.001).The sensitivity and specificity of serum miR-34a-5p and miR-17-5p for predicting secondary heart fail-ure were 0.875 and 0.802,respectively.Conclusions The levels of miR-34a-5p and miR-17-5p are increased in IDCM patients.These levels are correlated with heart failure and have predictive value for the condition.
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