Effect of hyperbaric oxygen combined with esomeprazole in the treatment of chronic insomnia with anxiety and its effect on inflammatory cell related factors
Objective To investigate the effect of hyperbaric oxygen combined with estazolam on patients with chronic insomnia accompanied by anxiety and its mechanism of action on inflammatory cytokines.Methods 96 patients with chronic insomnia and anxiety at Anyang People's Hospital from May 2021 to March 2023 were selected and divided into a study group and a control group by random number table,with 48 cases in each group.The control group received treatment with estazolam,and the study group was treated with hyperbaric oxygen combined with estazolam.The therapeutic effects and adverse reactions of the two groups were compared,and the anxiety (SAS score),sleep quality (PSQI score),inflammatory cytokine lev-els[interleukin-1β (IL-1β),tumor necrosis factor-α (TNF-α)],and hypothalamic-pituitary-adrenal axis (HPA axis) related factors[corticotropin-releasing hormone (CRH),adrenocorticotropic hormone (ACTH)]levels before and after treatment were compared between the two groups.Results The total effective rate of the treatment group was higher than that of the control group,and the difference was statistically significant (x2=4.360,P<0.05).The SAS and PSQI scores after treatment in the treatment group were lower than those in the control group,and the differences were statistically significant (t=6.087,2.895,P<0.05).The levels of IL-1β and TNF-α after treatment in the treatment group were lower than those in the control group,and the dif-ferences were statistically significant (t=3.579,7.291,P<0.05).The levels of plasma CRH and ACTH after treatment in the treatment group were lower than those in the control group,and the differences were statisti-cally significant (t=3.255,2.340,P<0.05).The total incidence of adverse reactions in the treatment group (4.17％) was not significantly different from that in the control group (6.25％),and the difference was not sta-tistically significant (x2=0.000,P>0.05).Conclusion Hyperbaric oxygen therapy combined with estazolam is an effective treatment for patients suffering from chronic insomnia and anxiety.This combination can signifi-cantly improve both sleep quality and psychological status.The molecular mechanism behind this treatment's success may be related to the regulation of inflammatory cytokines and factors related to the HPA axis.
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