Diagnostic efficacy of HbA1c combined with NT-proBNP test for early detection of the risk of near-term death in acute heart failure
Objective To explore the predictive value of HbA1c combined with B-type brain natro-titanium precursor biomarker (NT-proBNP) in the risk of near-term death in patients with acute heart failure.Methods From February 2020 to February 2023,103 patients with acute heart failure admitted to the First People's Hospital of Mengcheng County were included in the observation group.A total of 101 healthy patients who underwent physical examinations in the physical examination center of our hospital during the same period as the observation group and all indicators showed normal were selected as the control group.The levels of HbA1c and NT-proBNP were compared between the different groups of individuals.The correlation and diag-nostic value between HbA1c,NT proBNP and the risk of recent mortality in patients with acute heart failure were analyzed,along with the risk factors affecting mortality in patients with acute heart failure.Results The levels of serum HbA1c and NT-proBNP in the observation group were significantly higher than those in the control group,and the differences were statistically significant (P<0.05).HbA1c and NT-proBNP in the obser-vation group showed a positively correlation with cardiac function grade (r=0.587,0.536,P<0.05).The pro-portion of NYAH gradeⅣ and the expression of HbA1c and NT-proBNP in the deceased group were higher than those in the surviving group,and the differences were statistically significant (P<0.05).Logistic regres-sion analysis showed that NYAH grade-Ⅳ,HbA1c and the increase of NT-proBNP expression were risk fac-tors for death in patients with acute heart failure (OR>1,P<0.05).The forest plot showed that NT-proBNP was the strongest factor associated with an increased risk of death in patients with acute heart failure (OR=2.491,95％CI 1.414-4.390).The AUC value of combined detection (HbA1c and NT-proBNP) in patients with death from acute heart failure was higher than that of HbA1c and NT-proBNP alone,and the difference was statistically significant (P<0.05).Conclusion The levels of HbA 1 c and NT-proBNP increased with the severity of heart failure in patients who died from acute HF.When combined,HbA 1 c and NT-proBNP were predictors of the risk of death in patients with acute heart failure.
Acute heart failureHbA1cNT-proBNPRisk of near-term death
万方数据
维普
