Objective To investigate the predictive efficacy of lymphocyte/monocyte ratio (LMR) and mean platelet volume/lymphocyte ratio (MPVLR) in immunotherapy-related adverse thyroid events (TFA-IRAEs) in cases with advanced malignant tumors.Methods A total of 110 cases with advanced malignant tumors who received PD-1/PD-L1 inhibitors at Guangde People's Hospital from January 2020 to De-cember 2022 were selected.They were divided into two groups:the TFA-IRAE group (61 cases) and the non-TFA-IRAE group (49 cases) based on the presence or absence of TFA-IRAE.Peripheral blood LMR and MPVLR were detected and compared between the two groups.The predictive value of LMR and MPVLR for TFA-IRAE in patients with advanced malignant tumors was analyzed using ROC analysis.The influencing fac-tors of TFA-IRAE in cases with advanced malignant tumors were explored through Binary Logistic stepwise re-gression analysis.Results The LMR in the TFA-IRAE group was lower than that in the non-TFA-IRAE group,while the MPVLR in the TFA-IRAE group was higher than that in the non-TFA-IRAE group (P<0.05).The AUC (95％CI) of LMR and MPVLR for predicting TFA-IRAE in cases with advanced malignant tumors was 0.829 (0.784～0.879) and 0.756 (0.711～0.806),respectively.The AUC (95％CI) of combined prediction was 0.914 (0.870～0.963).There was no significant difference in TNM stage,underlying diseases (hypertension,diabetes,coronary heart disease,chronic obstructive pulmonary disease),smoking history,drinking history,and immunotherapy line number between the two groups (P>0.05).The proportion of females and individuals aged ≥ 60 years in the TFA-IRAE group was higher than that in the non-TFA-IRAE group (P<0.05).Female (OR=2.394,95％CI:1.227～4.671),LMR ≤3.73 (OR=3.294,95％CI:1.639～6.618),MPVLR ≥5.23 (OR=4.693,95％CI:1.985-11.094) were the influencing factors of TFA-IRAE in patients with advanced malignant tumors (P<0.05).Conclusion Low LMR and high MPVLR are associated with TFA-IRAE in patients with advanced malignant tumors.These markers can be used as laboratory indicators to pre-dict TFA-IRAE in cases of advanced malignant tumors.
维普
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