Expression and clinical significance of miR-26b,miR-15b,miR-204-5p and miR-200a in pregnancy-induced hypertension
Objective To investigate the expression and clinical significance of miRNA (miR)-26b,miR-15b,miR-204-5p and miR-200a in pregnancy-induced hypertension.Methods The clinical data of 83 pa-tients with pregnancy-induced hypertension who were admitted to Chengde Maternal and Child Health Hospital from January 2022 to January 2023 were retrospectively selected for the case group.Among them,28 cases of pregnancy-induced hypertension were used as the pregnancy-induced hypertension group,28 cases of mild pre-eclampsia as the mild preeclampsia group and 27 cases of severe preeclampsia as the severe preeclampsia group.In addition,94 normal full-term singleton pregnant women who received regular perinatal care and were admitted to the hospital for delivery were randomly selected as the control group.Results Systolic blood pres-sure and diastolic blood pressure followed this order:severe preeclampsia group>mild preeclampsia group>pregnancy-induced hypertension group>control group,the difference was statistically significant (P<0.05).The levels of serum miR-26b,miR-15b,miR-204-5p and miR-200a were as follows:severe preeclampsia group>mild preeclampsia group>pregnancy-induced hypertension group>control group,and the difference was statistically significant (P<0.05).The AUC value for the combined detection of serum levels of miR-26b,miR-15b,miR-204-5p and miR-200a in the diagnosis of pregnancy-induced hypertension was 0.940,which was higher than each indicator detected separately (0.768,0.809,0.744,0.795,P<0.05).The total incidence of adverse pregnancy outcomes in the case group was significantly higher than in the control group (P<0.05).Conclusion Patients with pregnancy-induced hypertension were more likely to have a poor pregnancy out-come.Serum levels of miR-26b,miR-15b,miR-204-5p and miR-200a were found to be significantly higher in patients with pregnancy-induced hypertension.The expression levels of these microRNAs were also correlated with the severity of the patient's condition.Combined detection of all four microRNAs showed higher diagnos-tic value for pregnancy-induced hypertension.
万方数据
维普
