Expression of IFN-γ and MMP-9 in pulmonary tuberculosis and its correlation with disease activity
Objective To analyze serum interferon-γ (Interferon gamma,IFN-γ),the expression of matrix metalloproteinase-9 (MMP-9) levels in pulmonary tuberculosis and its association with disease activ-ity.Methods 264 suspected pulmonary tuberculosis patients admitted to the First Affiliated Hospital of Xinx-iang Medical College from January 2019 to December 2022 were selected as the subjects of the study.After diag-nosis,they were divided into a tuberculosis group (n=204 cases) and a non-tuberculosis group(n=60 cases).The tuberculosis group was further categorized based on disease activity into an active pulmonary tuberculosis group (n=86 cases) and a non-active pulmonary tuberculosis group (n=118 cases).In addition,80 healthy indi-viduals who underwent physical examinations in our hospital during the same period were selected as the control group.The serum levels of IFN-γ and MMP-9 were compared between the active pulmonary tuberculosis group,the non-active pulmonary tuberculosis group,and the mild and severe active tuberculosis subgroups within the active tuberculosis group.The diagnostic efficacy of IFN-γ and MMP-9,both individually and in combination,for detecting pulmonary tuberculosis was analyzed.The serum levels of IFN-γ and MMP-9 in pa-tients with mild and severe cases of active pulmonary tuberculosis were compared,and the correlation factors affecting the severity of active pulmonary tuberculosis patients were analyzed by multivariate logistic regres-sion.Results The comparison of serum IFN-γ and MMP-9 levels among three groups showed that the tuber-culosis group>non tuberculosis group>healthy group,and the differences among the three groups were statis-tically significant (P<0.05).The sensitivity,specificity,and accuracy of combined diagnosis using MMP-9 were 93.55％,61.54％,and 84.09％,respectively,which were higher than those detected separately by the three methods (P<0.05).Among 204 pulmonary tuberculosis patients,86 were active pulmonary tuberculosis patients,and 118 were non-active pulmonary tuberculosis patients.The average levels of serum IFN γ and MMP-9 in active pulmonary tuberculosis patients were significantly higher than in non-active pulmonary tuber-culosis patients,with a statistically significant difference (P<0.05).In the evaluation of the condition,54 cases were mild and 32 cases were severe among the 86 patients with active pulmonary tuberculosis.Severe pa-tients with active pulmonary tuberculosis had a longer course of mild disease,higher smoking rates,and sig-nificantly higher levels of serum IFN-γ and MMP-9 comparedc to mild patients,with a statistically significant difference (P<0.05).According to logistic regression analysis,smoking,serum IFN-γ and MMP-9 are re-lated factors affecting the severity of active pulmonary tuberculosis patients (P<0.05).Conclusion Serum levels of IFN-γ and MMP-9 in patients with pulmonary tuberculosis are significantly increased,and the combi-nation of the two has good diagnostic efficacy for pulmonary tuberculosis.It is an important influencing factor affecting the severity of active pulmonary tuberculosis,and has important value for the assessment of pulmo-nary tuberculosis.
万方数据
维普
