Relationship of CXCR1,ESM-1 and IGFBP-2 with disease severity and prognosis in patients with COPD and pulmonary infection
Objective To analyze the relationship of levels of serum chemokine receptor 1 (CXCR1),endothelial cell specific molecule-1 (ESM-1) and insulin-like growth factor binding protein 2 (IGFBP-2) with disease severity and prognosis in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary infection.Methods 325 patients with COPD who were treated at Fuy-ang People's Hospital were selected from January 2021 to January 2023.The patients were divided into an in-fected group and a non-infected group based on pulmonary infection status.The levels of serum CXCR1,ESM-1 and IGFBP-2,as well as levels of conventional infection indicators[C-reactive protein (CRP) and procalcito-nin (PCT)]were compared between the two groups puon admission.The Pearson correlation coefficient was used to analyze the relationship among these indicators in the infected group.The levels of CXCR1,ESM-1,and IGFBP-2 at admission were compared among COPD patients with pulmonary infection of different disease severities.The infected patients were followed up for 6 months or until death and were then divided into a sur-vival subgroup and a death subgroup based on their prognosis status.The levels of serum CXCR1,ESM-1,and IGFBP-2 between these two subgroups were compared at admission.Finally,the predictive value of these indicators on the death of patients with COPD and pulmonary infections was analyzed using a receiver operat-ing characteristic curve (ROC).Results 325 patients with COPD were included in the study,with 109 cases in the infected group and 216 cases in the non-infected group.The levels of serum CXCR1,ESM-1,IGFBP-2,CRP,and PCT in the infected group at admission were higher than those in the non-infected group (P<0.05).There were statistically significant differences in serum CXCR1,ESM-1,and IGFBP-2 levels at admis-sion among patients with COPD and pulmonary infection of different disease severities (P<0.05).Pearson cor-relation coefficient analysis showed that serum CRP level in the infected group at admission was positively cor-related with CXCR1 and ESM-1 levels (P<0.05).During follow-up,19 cases (17.43％) died,and 90 cases (82.57％) survived in the infected group.The levels of serum CXCR1,ESM-1,and IGFBP-2 at admission in the death subgroup were higher compared with those in the survival subgroup (P<0.05).ROC results revealed that serum CXCR1 and IGFBP-2 levels had limitations in predicting the death of patients with COPD and pul-monary infection (AUC=0.636,0.769),while ESM-1 had good predictive efficiency (AUC=0.827).CXCR1+ESM-1+IGFBP-2 showed the best predictive efficiency (AUC=0.904).Conclusion Serum levels of CXCR1,ESM-1,and IGFBP-2 have a significant role in evaluating the severity of disease and prognosis in pa-tients with COPD and pulmonary infections.
Chronic obstructive pulmonary diseasePulmonary infectionChemokine receptor 1Endothelial cell specific molecule-1Insulin-like growth factor binding protein 2
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