Predictive value of Hsp90α,CER and AFP for the curative effect of TACE in patients with primary liver cancer
Objective To analyze the predictive value of serum Hsp90α,CER and AFP for the cura-tive effect of TACE in patients with primary liver cancer.Methods A total of 70 patients with primary liver can-cer undergoing TACE at Linquan County People's Hospital were enrolled as research subjects between January 2020 and January 2023.The postoperative curative effect was evaluated using mRECIST at 2 months after sur-gery,and the treatment response rate was calculated.Based on the curative effect,patients were divided into a good group and a poor group.The baseline data,levels of serum Hsp90α,CER,and AFP were compared between the two groups.The predictive value of the serum indicators mentioned above for the curative effect of TACE was analyzed using ROC curves.Results In the 70 patients with primary liver cancer,the response rate of TACE was 72.86％.There were significant differences in clinical staging and tumor boundary between the good group and poor group (t/x2=5.440,10.928,P<0.05).Before TACE,levels of serum Hsp90α,CER,and AFP in the poor group were higher than those in the good group (t=2.501,2.082,2.964,P<0.05).After TACE,levels of serum Hsp90α,CER,and AFP in the poor group were higher than those in the good group (t=7.196,6.866,8.687,P<0.05).Before TACE,levels of serum Hsp90α,CER,and AFP increased with the increase of clinical staging (F=4.966,4.817,7.878,P<0.05).The levels of serum Hsp90α,CER,and AFP in patients with irregular tu-mor boundaries were higher than those with regular tumor boundaries (t=8.169,3.434,10.276,P<0.05).ROC curve analysis showed that the AUC of serum Hsp90α combined with CER and AFP before TACE for predicting the curative effect was the greatest (P<0.05).Conclusion Serum levels of Hsp90α,CER,and AFP can help predict the clinical effectiveness of TACE.These markers can provide a basis for clinical intervention.
万方数据
维普
