The role of PMS2,MTA1 and VCAM-1 in the evaluation of colon cancer and prognosis
Objective To investigate the role of postmeiotic protein 2 (PMS2),tumor metastasis-associated gene 1 (MTA1) and vascular cell adhesion molecule-1 (VCAM-1) in the evaluation of colon cancer and prognosis.Methods A total of 81 patients with colon cancer who were admitted to Zhengzhou Yihe Hospital from January 2019 to March 2021 were selected as the study subjects.All patients underwent surgical treatment.The expression of PMS2,MTA1 and VCAM-1 in colon cancer tissues and adjacent tissues of these patients was compared.The expression levels of PMS2,MTA1 and VCAM-1 in different pathological features were analyzed.The COX univariate and multivariate factors affecting the survival of patients with colon cancer were examined.The prognostic survival rates of patients with different PMS2,MTA1 and VCAM-1 expression were compared.Results The positive expression rates of PMS2,MTA1 and VCAM-1 in colon cancer tissues were significantly higher than those in adjacent tissues,and the differences were statistically significant (P<0.05).PMS2 (+),MTA1 (+) and VCAM-1 (+) in TNM stage Ⅲ～Ⅳ were higher than those in TNM stage Ⅰ～Ⅱ,PMS2 (+),MTA1 (+) and VCAM-1 (+) in lymph node metastasis were higher than those in no lymph node metastasis,PMS2 (+),MTA1 (+) and VCAM-1 (+) in low differentiation were higher than those in high and medium differentiation,and the differences were statistically significant (P<0.05).However,there was no significant difference in PMS2 (+),MTA1 (+) and VCAM-1 (+) between different tumor sizes (P>0.05).COX univariate analysis showed that tissue differentiation (G3),TNM stage (Ⅲ～Ⅳ),distant (yes),PMS2 (+),MTA1 (+),VCAM-1 (+) were the poor prognostic factors affecting the death of colon cancer patients (P<0.05).COX multivariate analysis showed that tissue differentiation (G3),TNM stage (Ⅲ～Ⅳ),distant metastasis (yes),PMS2 (+),MTA1 (+),VCAM-1 (+) were independent prognostic risk factors for death in patients with colon cancer (P<0.05).The survival rate of the PMS2 positive group was lower than that of the negative group,the difference was statistically significant (x2=6.688,P<0.05).The survival rate of the MTA1 negative group was lower than that of the positive group,and the difference was statistically significant (x2=7.161,P<0.05).The survival rate of the VCAM-1 negative group was lower than that of the positive group,and the difference was statistically significant (x2=9.527,P<0.05).Conclusion PMS2,MTA1 and VCAM-1 are highly expressed in colon cancer tissues.By detecting the expression of the three indicators,the severity and prognostic risk of the patients can be more accurately judged.
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