Predictive value of serum OPN and FGF23 levels for vascular calcification in maintenance hemodialysis patients
Objective To investigate the serum levels of osteopontin (OPN) and fibroblast growth factor 23 (FGF23) in patients with maintenance hemodialysis (MHD) and their predictive value on vascular calcification.Methods A total of 116 MHD patients admitted to the Second People's Hospital of Nanyang City,Henan Province from January 2021 to December 2023 were selected as the study objects.Ac-cording to whether the patients had vascular calcification,they were divided into a calcification group (74 cases) and a non-calcification group (42 cases).Serum OPN and FGF23 levels were compared between the two groups,and the risk factors of vascular calcification in MHD patients were analyzed.ROC curve was used to analyze the predictive value of serum OPN and FGF23 levels on vascular calcification in MHD patients.Results The dialysis age,blood phosphorus,alkaline phosphatase (ALP),C-reactive protein (CRP),com-plete parathyroid hormone (iPTH),OPN and FGF23 in the calcification group were higher than those in the non-calcification group,and the differences were statistically significant (P<0.05).The levels of serum OPN and FGF23 in MHD patients were severe calcification group>moderate calcification group>mild calcification group,the difference was statistically significant (P<0.05).Spearman correlation analysis showed that the de-gree of vascular calcification in MHD patients was positively correlated with serum OPN and FGF23 levels (r=0.889,0.863,P<0.05).Logistic analysis showed that the increase of dialysis age,blood phosphorus,ALP,CRP,iPTH,OPN and FGF23 in MHD patients were risk factors for vascular calcification (P<0.05).Receiver operating characteristic curve (ROC) curve analysis showed that the area under the curve (AUC) of serum OPN and FGF23 were 0.845,0.891 and 0.948,respectively,and the combined prediction was better than the single prediction (P<0.05).Conclusion Serum OPN and FGF23 levels are positively correlated with the de-gree of vascular calcification in MHD patients,and the combined detection of OPN and FGF23 has high pre-dictive value for vascular calcification in MHD patients.
万方数据
维普
