Correlation analysis of serum FT3,FT4,RC levels and short-term prognosis in patients with atherosclerotic cerebral infarction
Objective To analyze and compare the levels of serum free triiodothyronine (FT3),Free thyroxine (FT4) and remnant cholesterol (RC) in patients with atherosclerotic cerebral infarction (ACI),and to explore the relationships all of them and the short-term prognosis of ACI.Methods A total of 180 ACI patients who received intravenous thrombolytic therapy at Suzhou Hospital Affiliated to Anhui Medical University from January 2021 to October 2023 were enrolled in the ACI group.Additionally,180 healthy subjects were included as the control group.General data of the subjects were collected and compared.Radioimmunoassay was used to detect serum levels of FT3,FT4,and RC in both groups.Multiple logistic regression analysis was conducted to identify influencing factors.The ROC curve was used to evaluate diagnostic value.Results The level of RC in the ACI group was significantly higher than that in the control group,and the levels of FT3 and FT4 in the ACI group were significantly lower than those in the control group (P<0.05).Hypertension,diabetes,the proportion of moderate and severe arterial stenosis,NIHSS score,hs-CRP,D-D,maximum diameter of infarct,LDL-C,and RC levels in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05).Serum FT3 and FT4 levels were also significantly lower in the poor prognosis group.High NIHSS score,high hs-CRP,high D-D,low FT3,low FT4,high RC,high maximum diameter of infarct,and moderate and severe arterial stenosis were identified as independent risk factors for poor prognosis in ACI patients (P<0.05).The area under curve (AUC) of serum FT3,FT4,RC and their combined diagnosis of poor prognosis in ACI patients were 0.869,0.832,0.840 and 0.951,respectively.The AUC of their combined diagnosis was significantly higher than that of their single diagnosis (P<0.05).Conclusion The abnormal levels of serum FT3、FT4 and RC are closely related to the occurrence and development of ACI.The combined detection of these levels has a high diagnostic value for predicting the prognosis of ACI patients.
万方数据
维普
