Relationship of serum ProGRP,CA242 and PCT levels with Hp infection and prognosis in patients with chronic atrophic gastritis
Objective To analyze the correlation between serum levels of ProGRP,CA242,PCT,Hp infection,and prognosis in patients with intestinal metaplasia of chronic atrophic gastritis.Methods 86 patients with chronic atrophic gastritis and intestinal metaplasia admitted to the First People 's Hospital of Mengcheng County from June 2020 to June 2022 were selected as the research subjects.According to whether they were infected with Hp,they were divided into group A (26 cases without Hp infection) and group B (60 cases with Hp infection).Based on the curative effect of Hp,group B patients were divided into a group with good prognosis (45 cases with curative Hp) and a group with poor prognosis (15 cases without curative Hp).The study aimed to compare the ProGRP,CA242,and PCT levels between group A and group B,as well as between the poor prognosis group and the good prognosis group,also to analyze the correlation between ProGRP,CA242,and PCT levels and Hp infection and prognosis.This study also aimed to evaluate the value of ProGRP,CA242,and PCT alone and in combination for detecting Hp infection in intestinal metaplasia of chronic atrophic gastritis.Results The levels of ProGRP,CA242 and PCT in group B were higher than those in group A,and the differences were statistically significant (t=7.927,8.288,5.419,P<0.05).ProGRP,CA242 and PCT levels in the poor prognosis group were higher than those in the good prognosis group (t=11.092,6.897,3.788,P<0.05).ProGRP,CA242,and PCT levels were positively correlated with HP infection and poor prognosis (r=0.723,0.711,0.688,0.725,0.722,0.701,P<0.05).The ROC curve showed that the AUC of combined diagnosis was 0.912,which was higher than 0.899,0.871 and 0.886 of ProGRP,CA242 and PCT alone (P<0.05).Conclusion The levels of ProGRP,CA242,and PCT are closely related to Hp infection and prognosis in patients with chronic atrophic gastritis and intestinal metaplasia.The combined detection of the three markers has high diagnostic value for Hp infection in patients with chronic atrophic gastritis and intestinal metaplasia.
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