Effects of freeze-dried recombinant human brain natriuretic peptide on NT-proBNP,AngⅡ,NE levels,ventricular remodeling and inflammatory factors in ischemic cardiomyopathy and heart failure patients
Objective To investigate the effects of lyophilized recombinant human brain natriuretic peptide on levels of NT-proBNP,AngⅡ,NE,ventricular remodeling and inflammatory factors in ICM HF patients.Methods Eighty-six patients with ICM HF from our hospital were selected from October 2020 to February 2023.They were divided into a control and a trial groups,with 43 cases in each group using randomized numerical table method.The control group received conventional treatment,while the trial group was treated with lyophilized recombinant human brain natriuretic peptide in addition to conventional treatment for 2 weeks.After 2 weeks of treatment,the efficacy of both groups was evaluated.Serum levels of NT-proBNP,AngⅡ,NE,ventricular remodeling index,and inflammatory factors were compared before and after 2 weeks of treatment in both groups.Results After 2 weeks of treatment,the total effective rate (93.02％) was higher in the trial group compared to the control group (74.42％),and the difference was statistically significant (x2=5.460,P<0.05).Serum levels of NT-proBNP,AngⅡ,NE,TNF-α,IL-6,IL-8,LVTWP,PWS,and IVSS were lower in both groups after 2 weeks of treatment compared to before treatment.Additionally,these levels were lower in the trial group,with statistically significant differences (t=5.672,20.016,55.416,6.742,5.851,5.258,5.940,6.681,5.865,P<0.05).Conclusion Freeze-dried recombinant human brain natriuretic peptide could reduce NT-proBNP,AngⅡ,and NE in serum.It can also improve neurosecretory function,inhibit ventricular remodeling and inflammation in ICM HF patients,leading to a noticeable therapeutic effect.
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