Effect of recombinant human growth hormone adjuvant therapy on serum FSH,E2 and LH levels in elderly infertile IVF-ET patients
Objective To investigate the effect of recombinant human growth hormone (rhGH) adjuvant therapy on serum follicle stimulating hormone (FSH),estradiol (E2) and luteinizing hormone (LH) levels in elderly infertile women during in vitro fertilization and embryo transfer (IVF-ET).Methods In this study,a retrospective analysis method was used to select 102 elderly infertile women admitted to Handan Central Hospital from January 2021 to August 2023.According to the treatment plan,they were divided into a control group treated with a gonadotropin-releasing hormone (GnRH) antagonist regimen,n=50 and the experimental group treated with GnRH antagonist regimen+rhGH adjuvant therapy,n=52.The results of ovulation induction,sex hormone levels (FSH,E2,LH),pregnancy outcomes and adverse reactions were compared between the two groups.Results The total dosage of Gn and the number of days of Gn use in the experimental group were less than those in the control group,and the difference was statistically significant (P<0.05).The total number of oocytes retrieved,the number of transplantable embryos and the number of high-quality embryos in the experimental group were higher than those in the control group,but the difference was not statistically significant (P>0.05).The levels of FSH,E2 and LH in the two groups decreased after treatment,with the levels in the experimental group being lower than those in the control group,and the differences were statistically significant (P<0.05).After treatment,the cycle cancellation rate and abortion rate in the experimental group were lower than those in the control group,and the clinical pregnancy rate and live birth rate were higher than those in the control group,but the differences were not statistically significant (P>0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group (P>0.05).Conclusion Compared to the GnRH-a regimen alone,the GnRH-a+rhGH adjuvant regimen can significantly regulate the levels of FSH,LH,and E2 in women with advanced infertility.It also improves the number of eggs obtained,the rate of eugenic embryos,and the rate of clinical pregnancy.
Recombinant human growth hormoneInfertilityIVF-ETFSHE2LH
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