Correlation of TKI comPliance and clinical outcome in Patients with chronic myelogenous leukemia
Objective To explore the correlation between adherence to tyrosine kinase inhibitors (TKIs) and clinical outcomes in patients with chronic myeloid leukemia (CML).Methods A total of 80 CML patients treated at Suzhou Hospital Affiliated with Anhui Medical University from January 2020 to June 2023 were selected for this study.The Chinese version of the Morisky Medication Adherence Scale (MMAS-8) was used to assess the patients' adherence to TKI therapy.Based on the assessment results,the patients were divided into a high adherence group and a low adherence group.A multivariate Cox proportional hazards model was employed to analyze factors related to adherence in the two groups.Additionally,TKI switching rates,major molecular response (MMR) rates,progression-free survival (PFS),and quality of life scores were compared between the two groups.Results The multivariate analysis using the Cox regression model in-dicated that male patients,those younger than 70 years old,those with high income,and those who main-tained frontline TKI therapy had higher adherence,which was associated with significantly improved clinical outcomes (P<0.05).The TKI switching rate in the high adherence group was significantly lower than that in the low adherence group,with a statistically significant difference (P<0.05).The MMR response rate in the high adherence group was significantly higher than that in the low adherence group,also showing a statistically significant difference (P<0.05).Kaplan-Meier survival analysis revealed that the progression-free survival in the high adherence group (62.35±12.39) was significantly longer than that in the low adherence group (39.04±10.07),with a statistically significant difference (P<0.05).Furthermore,the quality of life scores in the high adherence group were significantly higher than those in the low adherence group,with a statistically significant difference (P<0.05).Conclusion CML patients with high adherence to TKI therapy exhibit significantly bet-ter clinical outcomes.Therefore,clinical interventions should be strengthened to improve patient adherence to TKI therapy,thereby enhancing prognosis.
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