Changes in AAPR levels in patients undergoing gallstone surgery and their significance in evaluating disease outcomes
Objective To investigate the change of serum albumin (ALB) to alkaline phosphatase (ALP) ratio (AAPR) in patients with gallstone surgery and its significance in evaluating the outcome of the disease.Methods 126 patients who underwent gallstone surgery at Dezhou Hospital of Qilu Hospital,Shandong University from November 2021 to December 2023 were selected as the study group.Based on the effectiveness of the surgery,the study group was divided into a good prognosis group (n=91) and a poor prognosis group (n=35).Additionally,100 healthy individuals from our hospital during the same period were selected as the control group.The levels of ALB and ALP in all patients were measured and the AAPR was calculated.The receiver operating characteristic (ROC) curve was used to analyze the evaluation value of ALB,ALP levels,and AAPR on the disease prognosis of patients who had undergone gallstone surgery.Univariate analysis was conducted on the general data of patients with different prognoses.Statistically significant indicators were then included in the multivariate logistic regression equation to analyze the influencing factors of disease prognosis in patients who had undergone gallstone surgery.Results ALB and AAPR in the study group were lower compared to the control group,and ALP was higher (P<0.05).ALB and AAPR in the good prognosis group were higher than those in the poor prognosis group,and ALP was lower (P<0.05).The AUC assessed by ALB and ALP were 0.746 and 0.827,respectively,and the AUC assessed by AAPR was 0.941.The proportion of laparoscopic surgery in the group with a good prognosis is significantly higher than that in the group with a poor prognosis,and the C-reactive protein (CRP) level was lower than that in the poor prognosis group (P<0.05).CRP,ALB,ALP,and AAPR were the influencing factors of disease outcome in patients with gallstone surgery (P<0.05).Conclusion Low expression of AAPR in patients who have undergone gallstone surgery is associated with a poor disease outcome.This suggests that AAPR could serve as a potential marker for evaluating the disease outcome in these patients.
万方数据
维普
