Clinical efficacy and related laboratory indexes of modified tingladaozxiefei decoction in the treatment of children's bronchopneumonia
Objective To analyze the curative effect of modified tingladaozxiefei decoction on chil-dren with bronchopneumonia and its influence on TNF-α,IL-10,CRP,PCT and immune function.Methods One hundred and sixteen children with bronchopneumonia were admitted to The First Affiliated Hospital of An-hui University of Traditional Chinese Medicine Guoyang Branch Guoyang Traditional Chinese Medicine Hospi-tal from June 2021 to September 2023.They were divided into a study group (n=58) and a control group (n=58).Both groups received routine cough relief,expectorants and antibiotic treatments,while the study group was treated with modified tingladaozxiefei decoction for one week.The changes of serum inflammatory factors,T lymphocyte subsets in peripheral blood and lung function were compared between the two groups before and after treatment.The recovery time of symptoms and signs in the two groups was recorded and the clinical effi-cacy of the two groups was evaluated after treatment.Results Compared to before treatment,FVC,FEV1 and PEF in the two groups increased significantly after one week of treatment,and the difference was statistically significant (t=3.197,10.144 and 2.415,P<0.05).The total fever,cough,wheezing,lung rales and hospitaliza-tion time in the study group were lower than those in the control group,and the differences were statistically sig-nificant (t=10.086,6.588,6.739,12.138,10.260,P<0.05).After one week of treatment,the total effective rate of the study group was 94.83％,which was higher than that of the control group (79.31％),with statistical significance (x2=6.202,P<0.05).After one week of treatment,TNF-α,IL-10,CRP and PCT in both groups decreased compared with those before treatment.Compared with the control group,the study group was lower,and the difference was statistically significant (t=3.309,4.780,4.524,18.385,P<0.05).After one week of treatment,CD4+and CD4+/CD8+in the two groups were higher than those before treatment and higher than those in the control group,with statistical significance (t=2.903,2.415,P<0.05).CD8+decreased compared with before treatment,and the observation group was lower than the control group,with statistical significance (t=2.125,P<0.05).Conclusion In the treatment of children's bronchopneumonia,the addition and subtrac-tion of Keli Dazao Xiefei Decoction can lead to a more significant curative effect.
Tinglidazaoxiefei decoctionChildrenBronchopneumoniaImmunologic function
万方数据
维普
