Changes of serum NSE,IL-1β and 5-HT levels in patients with chronic insomnia disorder and relationship with cognitive function and sleep
Objective To explore the changes of serum neuron-specific enolase (NSE),interleu-kin-1β (IL-1β) and 5-hydroxytryptamine (5-HT) levels in patients with chronic insomnia disorder and the rela-tionship with cognitive function and sleep.Methods The clinical data of 90 patients with chronic insomnia dis-order at the Qingdao Special Servicemen Recuperation Center of the People's Liberation Army Navy were ana-lyzed from August 2021 to August 2023.Based on the sleep quality status at admission,the patients were di-vided into three groups:severe (n=39),moderate (n=30),and mild (n=21).The levels of serum NSE,IL-1β,and 5-HT at admission were compared among these groups.Using the Montreal Cognitive Assessment Scale (MoCA),cognitive function of patients with chronic insomnia disorder at admission,the patients were further classified into two subgroups:insomnia with cognitive dysfunction (n=41) and simple insomnia (n=49).The relationship between serum levels of NSE,IL-1β,and 5-HT at admission and MoCA score was then compared between these two subgroups.Pearson correlation coefficient was used to analyze the correlation between the lev-els of serum NSE,IL-1β,and 5-HT at admission and MoCA score in patients with chronic insomnia disorder.A receiver operating characteristic (ROC) curve was applied to analyze the diagnostic efficiency of serum NSE,IL-1β,and 5-HT levels at admission for patients with insomnia and cognitive dysfunction.Results The levels of NSE and IL-1β showed severe group>moderate group>mild group (F=76.815,34.153;P<0.05) while the 5-HT level was manifested as severe group<moderate group<mild group (F=130.092;P<0.05).The NSE and IL-1β levels in insomnia with cognitive dysfunction group were significantly higher than those in simple in-somnia group (t=9.397,5.274;P<0.05),while the 5-HT was significantly lower than that in the simple insom-nia group (t=9.703;P<0.05).Pearson correlation coefficient analysis showed that serum NSE and IL-1β levels at admission were significantly negatively correlated with MoCA score in insomnia with cognitive dysfunction group (P<0.05),and 5-HT level was significantly positively correlated with MoCA score (P<0.05).ROC analysis,the ACU of combined detection with serum NSE,IL-1β,and 5-HT was 0.966,which was better than that of single detection (P<0.05).Conclusion The cognitive function and sleep of patients with chronic insomnia disorder are related to increase in NSE and IL-1β,and decrease in 5-HT.
Chronic insomnia disorderSerum NSEIL-1β5-HTCognitive function
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