Effects of exercise rehabilitation intervention on cardiac function,autophagy and mTOR pathway of patients with chronic heart failure
Objective To investigate the effects of exercise rehabilitation intervention on cardiac function,autophagy and mammalian target of rapamycin (mTOR) pathway of patients with chronic heart failure (CHF).Methods CHF patients admitted to our hospital from January 2021 to December 2023 were randomly divided into an observation group (n=43,receiving conventional anti-heart failure therapy combined with exercise rehabilitation intervention) and a control group (n=44,receiving conventional anti-heart failure therapy).Three months after treatment,left ventricular ejection fraction (LVEF),NT-terminal pro-brain natriuretic peptide (NT-proBNP),6-minute walking distance (6MWD),Minnesota Living with Heart Failure Questionnaire,MLHFQ) score,serum light chain protein 3-Ⅱ(LC3-Ⅱ),Beclin-1,autophagy associated protein 9a (Atg9a),myoglobin (Myo),creatinine(Cr),alanine aminotransferase (ALT),aspartate aminotransferase (AST),and peripheral blood mRNA expression levels of PI3K,AKT and mTOR were compared.Results 3 months after treatment,LVEF level,6MWD,serum LC3-Ⅱ,Beclin-1 and Atg9a levels in the observation group were higher than those in the control group,while serum NT-proBNP level,MLHFQ score and peripheral blood PI3K,AKT and mTOR mRNA expression levels were lower than those in the control group (t=3.676,7.814,6.978,11.593,14.147,P<0.05),the difference was statistically significant (t=9.183,16.140,14.315,13.383,8.634,P<0.05).There were no significant differences in serum levels of Myo,Cr,ALT and AST between the two groups (t=0.673,0.434,0.335,0.635,P>0.05).Conclusion Exercise rehabilitation can improve cardiac function,activate autophagy and inhibit the PI3K/AKT/mTOR pathway in patients with CHF.
万方数据
维普
