Effect of remifentanil combined anaesthesia on serum IL-6,IL-2 and T-lymphocyte subsets in patients undergoing laparoscopic cholecystectomy
Objective To investigate the effects of remifentanil combined anaesthesia on serum IL-6,IL-2 and T-lymphocyte subpopulations in patients undergoing laparoscopic cholecystectomy (LC).Methods A total of 122 patients who underwent LC at Wuwei People's Hospital from October 2019 to July 2023 were se-lected as the research subjects.According to different anesthetic drugs,they were divided into the control group (n=59,sevoflurane+propofol combined anesthesia) and the observation group (n=63,remifentanil+propofol combined anesthesia).The recovery of anesthesia,serum levels of IL-6 and IL-2,changes of T lymphocyte subsets and adverse reactions were compared between the two groups.Results The postoperative awakening time,recovery time of spontaneous respiration and catheter removal time of the observation group were shorter than those of the control group,and the difference was statistically significant (P<0.05).The levels of IL-6 and IL-2 at T0 for both groups were compared,and the difference was not statistically significant (P>0.05).At T1 (6 hours postoperatively),T2 (12 hours postoperatively) and T3 (24 hours postoperatively),the IL-6 level of the observation group was lower than that of the control group,and the IL-2 level was higher than that of the control group,and the difference was statistically significant (P<0.05).When comparing the two groups at T0,there was no statistical significance in the comparison of CD3+,CD4+,CD8+and CD4+/CD8+(P>0.05).However,the T1,T2 and T3,CD3+,CD4+,and CD4+/CD8+levels in the observation group was higher than that in the control group,and CD8+was higher than that in the control group,and the difference was statistically significant (P<0.05).When comparing the incidence rate of adverse reactions between the two groups,the difference was not statistically significant (P>0.05).Conclusion Compared to sevoflurane combined anaesthesia,remifentanil combined anaesthesia has a lesser effect on serum IL-6 and IL-2 levels in LC patients,impacting the immune system less.Additionally,it can accelerate postoperative patient wakefulness and anaesthesia recovery with moderate safety.
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