Relationship between OPN,CRP and RANKL levels in gingival crevicular fluid and periimplant inflammation
Objective To analyze the relationship between the levels of osteopontin (OPN),C-reactive protein (CRP) and receptor activator of nuclear factor-kB ligand (RANKL) in gingival crevicular fluid and peri-implantitis (PI).Methods 87 cases of PI patients admitted to the Dental Department of Boe Hospital,Chengdu from Jun 2021 to Mar 2023 were retrospectively analyzed as the PI group.Another 80 patients undergoing dental implant restoration with healthy implants were selected as control group.The levels of OPN,CRP,RANKL and periodontal clinical indicators were compared between the two groups,and the correlation between OPN,CRP,RANKL levels and PI was analyzed.The prognosis was counted,and the levels of OPN,CRP and RANKL in patients with different prognosis in PI group were compared.Results The levels of OPN,CRP,and RANKL were higher in the PI group than in the control group,and the difference was statistically significant (P<0.05).The improved gingival index,d bleeding index,and probing depth of the PI group were also higher than those of the control group (P<0.05).There was a positive correlation between OPN,CRP,and RANKL and the improved gingival index,bleeding index,and probing depth (P<0.05).It was found that 58 out of 87 patients had a good prognosis,and 29 had a poor prognosis.OPN,CRP,and RANKL levels were higher in the poor prognosis group than in the good prognosis group,and the difference was statistically significant (P<0.05).Conclusion The levels of OPN,CRP and RANKL in the gingival sulcus fluid of patients with PI were found to be abnormally high and correlated with the modified gingival index,modified bleeding index score and probing depth.Therefore,assessing the prognosis of patients with PI can be done by detecting these levels in the gingival sulcus fluid.This information can provide a basis for clinical treatment.
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