Study on the predictive value of serum markers sTREM-1 and AQP5 for infectious endophthalmitis after cataract surgery
Objective To study the predictive value of serum markers soluble triggering receptor expressed on human myeloid cells-1 (sTREM-1) and aquaporin 5 (AQP5) for infectious endophthalmitis after cataract surgery.Methods 146 cataract patients who underwent surgical treatment at Chengdu Aier Ophthal-mology Hospital from October 2021 to October 2023 were selected as the observation group,and 120 healthy subjects who underwent physical examinations during the same period were selected as the control group.The differences of serum sTREM-1 and AQP5 levels between the two groups were compared.The observation group was further divided into an infected subgroup (n=31) and a non-infected subgroup (n=115) based on whether postoperative infectious endophthalmitis occurred after cataract surgery.The differences of serum sTREM-1 and AQP5 levels and clinical data between the two subgroups were compared,and the influencing factors of infec-tious endophthalmitis after cataract surgery were analyzed by binary logistic regression.The predictive value of serum sTREM-1 and AQP5 for infectious endophthalmitis after cataract surgery was analyzed by receiver operat-ing characteristic (ROC) curve analysis.Results The levels of serum sTREM-1 and AQP5 in the observation group were higher than those in the control group,the difference was statistically significant (t=13.235,12.484,P<0.05).The levels of serum sTREM-1 and AQP5,as well as the proportion of diabetes mellitus,op-eration time,intraoperative blood loss and proportion of vitreous spill in the infected subgroup were higher than those in the non-infected subgroup,with statistical significance (t=6.536,4.026,4.392,6.934,10.544,14.508,P<0.05).History of diabetes mellitus,prolonged operation time and increased levels of serum sTREM-1 and AQP5 were identified as risk factors for infectious endophthalmitis after cataract surgery (P<0.05).Serum sTREM-1 and AQP5 showed predictive value for infectious endophthalmitis after cataract surgery,and the pre-dicted areas under the curve were 0.807 and 0.905).Conclusion The elevation of serum sTREM-1 and AQP5 levels is correlated with infective endophthalmitis following cataract surgery.Both indexes hold predictive sig-nificance for the development of infective endophthalmitis post cataract surgery.
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