Effects of Jianpi Runfei Pills on levels of β-CAR,VEGF,IFN-γ,and IL-17 in patients with pulmonary tuberculosis
Objective To study the effects of Jianpi Runfei Pills on levels of β-carotene (β-CAR),vascular endothelial growth factor (VEGF),interferon-γ (IFN-γ),and interleukin-17 (IL-17) in patients with pulmonary tuberculosis.Methods A total of 120 patients with pulmonary tuberculosis admitted to Zhangjiakou Pulmonary Hospital from January 2020 to April 2023 were divided into the conventional group (60 cases) and the combined group (60 cases) by random number table method.Both groups were treated for 90 d.The study aimed to compare the efficacy,improvement in clinical symptoms,and signs,serum cytokine levels (β-CAR,VEGF,IFN-γ,IL-17),immune function (CD3+,CD4+,CD8+,CD4+/CD8+),lung function[forced expiratory volume (FEV1),forced vital capacity (FVC),FEV1/FVC]between two groups.Results After 90 days of treatment,the total effective rate of the combined group was higher than that of the conventional group,with statistical significance (P<0.05).In comparison to the conventional group,the combined group showed shorter duration of cough,sputum,short chest suffrage,disappearance time of hemoptysis chest pain,three consecutive negative rotations of acid-fast bacilli in sputum smear,and lung film focal shrinkage time,all with statistical significance (P<0.05).After 90 days of treatment,the levels of serum β-CAR,VEGF,IL-17 and the percentage of peripheral blood CD8+in 2 groups were lower than before treatment,and the combined group was lower than the conventional group,with statistical significance (P<0.05).The levels of serum IFN-γ,percentages of peripheral blood CD3+,CD4+and CD4+/CD8+,forced expiratory volume (FEV1),forced vital capacity (FVC),and FEV1/FVC increased compared to before treatment,with the combined group showing higher levels than the conventional group,all with statistical significance (P<0.05).Conclusion Jianpi Runfei pills could improve the levels of serum β-CAR,VEGF,IFN-γ,and IL-17,enhance immune function and lung function in patients with pulmonary tuberculosis.They also promote the improvement of clinical symptoms and signs in patients,showing a positive therapeutic effect.
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