Analyze the influencing factors of autologous hematopoietic stem cell mobilization in patients with multiple myeloma
Objective To analyze the influencing factors of autologous hematopoietic stem cell mo-bilization in patients with multiple myeloma.Methods A retrospective analysis was conducted on the clinical data of 38 multiple myeloma patients who were admitted to Anhui Public Health Clinical Center between March 2019 and April 2023.These patients underwent autologous hematopoietic stem cell mobilization with etoposide combined with G-CSF.The clinical data included age,gender,body mass index (BMI),disease subtype,num-ber of chemotherapy cycles,disease remission level,adverse reactions,number of CD34+cells collected,time from mobilization to collection,number of collections,pre-collection blood routine and lipid levels.The effi-cacy and safety of the mobilization regimen were evaluated.Based on the number of CD34+cells collected,pa-tients were divided into two groups:the advantageous collection group and the non-advantageous collection group.The differences in the aforementioned indicators between the two groups were analyzed,and prognostic factors affecting advantageous collection were investigated.Results The overall collection success rate for the 38 patients was 89.47％(34/38).The median time from mobilization to collection was 9 (6-11) days,with a me-dian number of collections of 1(1-3).The median CD34+cell count among successful collections was 5.15 (2.32-25.5)×106/kg.For the 6 patients who received plerixafor,the collection success rate was 100％(6/6),with a median CD34+cell count of 7.13(3.08-25.5)×106/kg.No statistically significant differences were ob-served in CD34+cell collection quantities among patients of different genders,ages,BMI levels,primary dis-ease remission levels,number of chemotherapy cycles,and disease subtypes (P>0.05).Pre-collection white blood cell levels were significantly positively correlated with CD34+cell counts (P<0.01).Multivariate regres-sion analysis showed that having more than four chemotherapy cycles before collection and low LDL-C levels were independent risk factors for advantageous collection (P<0.05).There were no significant statistical differ-ences in the incidence of adverse reactions between the two groups (P>0.05).Conclusion The mobilization regimen combining plerixafor has a high success rate and few adverse reactions,making it an ideal APBSC mo-bilization regimen for MM patients.The number of chemotherapy cycles and LDL-C levels before collection are effective indicators for predicting advantageous collection.
万方数据
维普
