The value of PCT,SAA and Treg factor assays in the antimicrobial treatment of multidrug-resistant bacterial infections
Objective To investigate the value of serum procalcitonin (PCT),blood amyloid (SAA) and regulatory T-cell (Treg)-associated factor assays in guiding antimicrobial drug therapy for patients with multidrug-resistant bacterial infections.Methods 380 cases of multidrug-resistant bacterial infections admitted to the First Affiliated Hospital of Hainan Medical College from January 2022 to July 2023 were selected (the test group),and 378 patients who underwent physical examinations in the hospital during the same period and were normal and healthy were selected as the control group.The study aimed to compare the serum PCT,SAA,transforming growth factor-β (TGF-β) and interleukin A7A (ILA7A) levels between the two groups,to analyze the single multifactorial factors affecting multidrug-resistant infections by using multivariate logistic regression model,and the serum PCT,SAA,TGF-β and ILA7A levels of the patients in the test group with different efficacies before and after the treatment.The levels of PCT,SAA,TGF-β and ILA7A individually and in parallel to assess the value of antibiotic treatment efficacy were analyzed.Results The serum PCT,SAA and ILA7A levels in the test group were higher than those in the control group,and the TGF-β level was lower than that in the control group,and the difference was statistically significant (P<0.05).Univariate regression analysis showed that serum PCT,SAA,TGF-β and ILA7A levels were single factors affecting multi-resistant infections,and further rows of multivariate logistic results showed that serum PCT (>0.5 μg/L),SAA (>10 mg/L),reduced TGF-β and elevated ILA7A were risk factors affecting multi-resistant infections (P<0.05).There were 307 cases in the effective group and 73 cases in the ineffective group.There was no statistically significant difference in the comparison of serum PCT,SAA,TGF-β and ILA7A between the two groups before treatment (P>0.05),and the levels of PCT,SAA and ILA7A in the effective group were lower than those in the ineffective group,and the level of TGF-β was higher than those in the effective group,with statistically significant differences after 7d of treatment (P<0.05).The ROC curve showed that the AUC of the four parallel assays of PCT,SAA,TGF-β and ILA7A for assessing the efficacy of antibiotic therapy was 0.762,which was significantly higher than that of the individual assays (P<0.05).Conclusion The levels of serum SAA,PCT,and Treg cell-associated factors play a significant role in guiding the antibiotic treatment of patients with multidrug-resistant infections.These indicators have the highest accuracy when tested in parallel,providing a certain basis for developing a reasonable treatment plan in clinical practice.
PCTSAAregulatory T cellsMultidrug-resistant infectionsAntibiotics
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