Changes of sLOX-1,sST2 and SREBP-1 in patients with coronary heart disease and their relationship with the severity of coronary lesions
Objective To explore the changes of serum soluble lectin-like oxidised low-density li-poprotein receptor-1 (sLOX-1),sterol regulatory element binding protein-1 (SREBP-1) and soluble growth stimulation expressed gene 2 (sST2) in patients with coronary heart disease (CHD) and their relationship with the severity of coronary lesions.Methods A total of 156 patients with CHD treated at Inner Mongolia Autono-mous Region People's Hospital were enrolled in the CHD group between April 2020 and April 2022.This group included 51 cases of stable angina pectoris (SAP) group,63 cases of unstable angina pectoris (UAP) and 42 cases of acute myocardial infarction (AMI).Additionally,50 healthy controls were enrolled during the same pe-riod as the healthy group.The levels of sLOX-1,sST2 and SREBP-1,and QRS wave duration were detected in all subjects.These indexes were compared between healthy controls and CHD patients,and among patients with different Gensini scores and number of lesions were compared.The relationship between sLOX-1,sST2,SREBP-1,the severity of coronary lesions,and QRS wave duration was analyzed using the Spearman correlation coeffi-cient.Results There were significant differences in sLOX-1,sST2,SREBP-1 levels and QRS wave duration among the SAP group,UAP group,AMI group and healthy group (P<0.05).The levels of sLOX-1,sST2 and SREBP-1 and QRS wave duration were gradually decreased in AMI group,UAP group,SAP group and healthy group,and the differences were statistically significant (P<0.05).There were significant differences in sLOX-1,sST2,SREBP-1 levels and QRS wave duration among 0-20 point group,20-40 point group and ≥ 40 point group (P<0.05).The levels of sLOX-1,sST2 and SREBP-1 and QRS wave duration were gradually decreased in ≥ 40 point group,20-40 point group and 0-20 point group,and the differences were statistically significant (P<0.05).There were significant differences in sLOX-1,sST2,SREBP-1 levels and QRS wave duration among triple-ves-sel group,double-vessel group and single-vessel group (P<0.05).The levels of sLOX-1,sST2 and SREBP-1 and QRS wave duration were gradually decreased in triple-vessel group,double-vessel group and single-vessel group,and the differences were statistically significant (P<0.05).Conclusion The levels of sLOX-1,SREBP-1 and sST2 in CHD patients are higher than those in healthy individuals,and they are correlated with the severity of coronary lesions.These markers can be applied as targets for the clinical prevention and treatment of CHD.
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