Analysis of IL-6,CRP,Hcy,ACA and prognosis of patients with acute cerebral infarction
Objective To analyze the relationship of interleukin-6 (IL-6),C-reactive protein (CRP),homocysteine (Hcy) and anticardiolipin antibody (ACA) with prognosis of patients with acute cerebral infarction (ACI).Methods The clinical data of 146 patients with ACI who received intravenous thrombolytic therapy at Qinhuangdao Workers' Hospital from September 2020 to September 2023 were retrospectively analyzed.The modified rankin score (mRS) was used to evaluate the prognosis of patients,who were then divided into a good prognosis group (n=109) and a poor prognosis group (n=37).General data,neurological deficit (NIHSS),and laboratory indicators including creatinine (Cr),total bilirubin (Tbil),albumin (ALB),red blood cell count (RBC),white blood cell count (WBC),platelet count (PLT),IL-6,CRP,Hcy,and ACA were compared between the two groups.A binary logistic regression model was used to analyze the influencing factors of prognosis in patients with ACI.The Pearson correlation coefficient was performed to analyze the correlation between laboratory indicators and the degree of prognosis in patients with ACI.A receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of IL-6,CRP,Hcy,and ACA on the prognosis of patients.Results The NIHSS score,IL-6,CRP,Hcy,and ACA levels were lower in the poor prognosis group (t=2.651,6.507,10.217,7.946,8.571,P<0.05).Regression analysis showed that high NIHSS score and elevated levels of IL-6,CRP,Hcy,and ACA were risk factors for poor prognosis in patients with ACI (P<0.05).The levels of IL-6,CRP,Hcy,and ACA were lower in the anterior circulation group compared to the posterior circulation group (t=5.314,8.547,5.219,9.087,P<0.05),and lower in the small-area infarction group than in the large-area infarction group (t=10.514,21.033,15.658,11.723,P<0.05).NIHSS score,IL-6,CRP,Hcy,and ACA were positively correlated with mRS score (r=0.523,0.584,0.572,0.545,0.521,P<0.05).The areas under the curves (AUCs) of NIHSS score,IL-6,CRP,Hcy,and ACA in predicting the prognosis of acute cerebral infarction were 0.622,0.759,0.894,0.845 and 0.892 respectively.IL-6,CRP,Hcy,and ACA had higher predictive efficiency compared to NIHSSscore (P<0.05).Conclusion The poor prognosis of patients with acute cerebral infarction is related to elevated levels of IL-6,CRP,Hcy,and ACA.Changes in these indicators can predict the prognosis of patients.
IL-6CRPHcyACAPrognosis of acute cerebral infarction
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