摘要
目的 探讨精神分裂症患者认知功能损害的危险因素,并分析血清学指标预测价值.方法 选择于2020年5月至2023年5月期间安庆市第六人民医院收治的103例精神分裂症患者,将其分组为损害组(MCCB评分<50分)、非损害组(MCCB评分≥50分).比较两组一般资料,采用多因素Logistic回归分析影响认知功能损害的危险因素,绘制ROC分析血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)与低密度脂蛋白胆固醇(LDL-C)水平检测对认知功能损害的预测价值.结果 103例精神分裂症患者中,认知功能损害发生率达64.08％(66/103);认知功能损害组年龄、受教育年限、住院次数、SAPS评分、SANS评分、BPRS评分、TC、TG、HDL-C、LDL-C与非损害组比较,差异有统计学意义(t/x2值=3.390、8.501、9.398、5.467、4.307、3.826、3.767、7.502、4.195和6.295,P<0.05).多因素Logistic回归分析,年龄增加、BPRS评分升高、SANS评分升高、TC升高、TG升高、HDL-C降低和LDL-C升高是精神分裂症患者出现认知功能损害的独立危险因素(P<0.05).ROC曲线结果显示,血清TC、TG、HDL-C和LDL-C预测精神分裂症患者认知功能损害的曲线下面积(AUC)均>0.65,预测效能较好.结论 精神分裂症患者认知功能损害发生率较高,年龄增加、BPRS评分升高、SANS评分升高、TC升高、TG升高、HDL-C降低和LDL-C升高是精神分裂症患者出现认知功能损害的独立危险因素,临床可以通过血脂水平检测评估认知功能损害发生.
Abstract
Objective To explore the risk factors of cognitive impairment in patients with schizophrenia,and to analyze the predictive value of serological indexes.Methods A total of 103 patients with schizophrenia were admitted to Anqing Sixth People's Hospital between May 2020 and May 2023.They were divided into two groups:the impairment group (MCCB score<50 points) and the non-impairment group (MCCB score ≥ 50 points).General data from both groups were compared.Risk factors for cognitive impairment were analyzed using multivariate logistic regression analysis.The predictive value of serum total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cognitive impairment was analyzed using ROC curves.Results In a study of 103 patients with schizophrenia,the incidence of cognitive impairment was 64.08％ (66/103).There were significant differences in age,education years,hospitalization frequency,scores of SAPS,SANS,and BPRS,as well as levels of TC,TG,HDL-C and LDL-C between the impairment group and the non-impairment group (t/x2=3.390,8.501,9.398,5.467,4.307,3.826,3.767,7.502,4.195,6.295,P<0.05).Multivariate logistic regression analysis showed that increased age,BPRS score,SANS score,TC,and TG,decreased HDL-C and increased LDL-C were independent risk factors for cognitive impairment in schizophrenia patients (P<0.05).The results of ROC curve analysis showed that the area under the curve (AUC) values of serum TC,TG,HDL-C,and LDL-C for predicting cognitive impairment were all>0.65,demonstrating good predictive efficiency.Conclusion The incidence of cognitive impairment is high in schizophrenia patients.Increased age,BPRS score,SANS score,TC,and TG,decreased HDL-C and increased LDL-C are independent risk factors for cognitive impairment.Clinically,detection of blood lipid levels can evaluate the occurrence of cognitive impairment.
基金项目
安徽省健康发展战略研究中心招标资政项目(2021szk013)
维普
万方数据