Risk factors of cognitive impairment and predictive value of serological indexes in patients with schizophrenia
Objective To explore the risk factors of cognitive impairment in patients with schizophrenia,and to analyze the predictive value of serological indexes.Methods A total of 103 patients with schizophrenia were admitted to Anqing Sixth People's Hospital between May 2020 and May 2023.They were divided into two groups:the impairment group (MCCB score<50 points) and the non-impairment group (MCCB score ≥ 50 points).General data from both groups were compared.Risk factors for cognitive impairment were analyzed using multivariate logistic regression analysis.The predictive value of serum total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cognitive impairment was analyzed using ROC curves.Results In a study of 103 patients with schizophrenia,the incidence of cognitive impairment was 64.08％ (66/103).There were significant differences in age,education years,hospitalization frequency,scores of SAPS,SANS,and BPRS,as well as levels of TC,TG,HDL-C and LDL-C between the impairment group and the non-impairment group (t/x2=3.390,8.501,9.398,5.467,4.307,3.826,3.767,7.502,4.195,6.295,P<0.05).Multivariate logistic regression analysis showed that increased age,BPRS score,SANS score,TC,and TG,decreased HDL-C and increased LDL-C were independent risk factors for cognitive impairment in schizophrenia patients (P<0.05).The results of ROC curve analysis showed that the area under the curve (AUC) values of serum TC,TG,HDL-C,and LDL-C for predicting cognitive impairment were all>0.65,demonstrating good predictive efficiency.Conclusion The incidence of cognitive impairment is high in schizophrenia patients.Increased age,BPRS score,SANS score,TC,and TG,decreased HDL-C and increased LDL-C are independent risk factors for cognitive impairment.Clinically,detection of blood lipid levels can evaluate the occurrence of cognitive impairment.
万方数据
维普
