Efficacy of butylphthalein combined with Edaravone dextrocamphorol in the treatment of arteriolar occlusion type stroke
Objective To investigate the efficacy of butaphthalein combined with eEdaravone dextrocamphorol in the treatment of small artery occlusion-type (SAO) stroke and the effects on serum vascular endothelial growth factor (VEGF),miR-34a and hypoxia-inducing factor-1 α (HIF-1α).Methods A total of 102 SAO stroke patients diagnosed and treated at Jieshou People's Hospital from March 2023 to March 2024 were selected for the study.They were randomly divided into two groups:the butylphthalein group (n=51,treated with butylphthalein) and the combination group (n=51,treated with butylphthalein treatment and Edaravone dexcarnol) using a random number table method.Cerebral hemodynamics,neurological function,serum miR-34a,VEGF,HIF-1α levels and adverse reactions were compared between the two groups.Results After treatment,the relative cerebral blood flow (rCBF),mean blood flow (Qm) and mean blood flow velocity (Vm) of the combination group were statistically higher than those before treatment and the butylphthalein group (t=5.038,3.297,3.308,3.608,P<0.05).After treatment,the Scandinavian Stroke Scale (SSS) score of the combination group was statistically higher than the SSS score of the butylphthalein group,and the levels of glial fibrillary acidic protein (GFAP) in the combination group were statistically lower than those before treatment and in the butylphthalein group (t=3.891,4.654,6.339,P<0.05).After treatment,the expression of HIF-1α and miR-34a in the peripheral blood of the combination group was statistically lower than before treatment and in the butylphthalein group,and the expression of VEGF was statistically higher than in the butylphthalein group and before treatment (t=6.436,5.591,4.217,P<0.05).There was no significant difference in adverse drug reactions between the two groups (x2=0.270,P>0.05).Conclusion The combination of buphthalein and Edaravone dextrocamphorol in the treatment of SAO stroke can improve cerebral hemodynamics and cerebral perfusion,enhance neurological function,reduce HIF-1α and miR-34a expression,and elevate VEGF levels.
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