Correlation between serum FIB,urine RBP,NAG,TRF and pathological grade of kidney in children with purpura nephritis
Objective To investigate the relationship between serum fibrinogen (FIB),urinary retinol-binding protein (RBP),urinary n-acetyl-β-D glucosaminase (NAG),transferrin (TRF) and renal pathological grade in children with purpura nephritis (HSPN).Methods A total of 114 children with HSPN admitted to Anhui Children's Hospital from January 2021 to May 2023 were selected as the study group,and divided into 63 cases of grade Ⅱ and 51 cases of grade Ⅲ according to pathological grade.In addition,57 hospitalized children with anaphylactoid purpura without renal injury were selected as the control group.The levels of serum FIB,urine RBP,NAG and TRF were compared between the two groups.The study group was also analyzed for the relationship between serum FIB,urine RBP,NAG and TRF and renal pathological grade.The predictive value of serum FIB and urine RBP was analyzed.Results The levels of serum FIB,RBP,NAG and TRF in the study group were higher than those in the control group (t value:3.160,11.001,2.882 and 4.168,respectively,P<0.05).The levels of serum FIB,RBP,NAG and TRF in grade Ⅲ group were higher than those in grade Ⅱ group (t value:3.995,10.123,4.324,2.893,P<0.05).Serum FIB,RBP and NAG were positively correlated with renal pathological grade (r value:3.995,10.123,4.324,2.893,P<0.05).ROC curve analysis showed that the AUC of serum FIB combined with urine RBP,NAG and TRF to predict purpura nephritis was 0.930,which was higher than that of each indicator alone.Conclusion Serum FIB,urine RBP,NAG and TRF levels are closely related to the pathological grade of HSPN children,and combined detection can be used as an effective index to judge HSPN
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