Influencing factors of intracranial infection and predictive value of NF-κB,PCT and IL-1β in cerebrospinal fluid after external ventricular drainage
Objective To explore the influencing factors of intracranial infection and the predictive value of NF-κB,PCT and IL-1β in cerebrospinal fluid after EVD.Methods A total of 227 EVD postoperative patients admitted to the Second People's Hospital of Nanning from November 2021 to November 2023 were se-lected and divided into two groups:an infected group (n=30) and a non-infected group (n=197) based on post-operative intracranial infection.Relevant clinical data and laboratory indicators were collected and compared be-tween the two groups,and the risk factors of intracranial infection after EVD were analyzed by multivariate lo-gistic analysis.The predictive efficacy of cerebrospinal fluid nuclear factor-κB (NF-κB),procalcitonin (PCT) and interleukin (IL) 1β on intracranial infection after EVD was analyzed using receiver operating characteristic curve (ROC).Results There were statistically significant differences between the two groups in ICU treatment time,occurrence of shock,presence of hypoproteinemia,duration of extraventricular drainage,levels of NF-κB,PCT and IL-1β in cerebrospinal fluid (x2/t=4.589,8.841,18.604,4.601,4.421,6.314,4.746,P<0.05).Multivariate logistic regression analysis showed that hypoproteinemia,external ventricular drainage duration>7 days and increased expression levels of NF-κB,PCT and IL-1β in cerebrospinal fluid were independent risk fac-tors for intracranial infection after EVD (OR=2.298,2.197,2.179,1.893,1.978),P<0.05).The ROC areas for NF-κB,PCT,IL-1β and their combined detection were 0.718,0.753,0.726 and 0.870,respectively (P<0.05).Conclusion The disturbance in the expression levels of NF-κB,PCT,and IL-1β in cerebrospinal fluid is a significant risk factor for intracranial infection following EVD.The combined detection of these three factors has a high predictive value for intracranial infection after EVD.
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