Efficacy of Zhenwu decoction on patients with chronic pulmonary heart disease and influence on levels of IL-8,PCT and hs-CRP
Objective To explore the influence of Zhenwu decoction on cardiopulmonary function and levels of interleukin (IL)-8,procalcitonin (PCT) and high-sensitivity C-reactive protein (hs-CRP) in patients with chronic pulmonary heart disease (CPHD).Methods The medical records of 98 patients with CPHD at Huaibei Hospital of Traditional Chinese Medicine were retrospectively analyzed from December 2021 to December 2023.48 patients treated with conventional Western medicine were included in the control group,and 50 patients who received conventional Western medicine combined with Zhenwu decoction were enrolled in the study group.The TCM syndrome scores,cardiopulmonary function,inflammatory cytokines before and after treatment and adverse reactions during treatment were observed in the both groups.Results After treatment,the scores of TCM syndromes,IL-8,PCT,hs-CRP,left ventricular end-diastolic diameter (LVEDd) and left ventricular mass index (LVMI) in the two groups decreased significantly (P<0.05).These indicators were lower in the study group compared to the control group (P<0.05).The forced vital capacity (FVC),forced expiratory volume in the first second (FEV1),ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) and left ventricular ejection fraction (LVEF) in the two groups after treatment significantly increased (P<0.05).The indicators in the study group were higher than those in the control group (P<0.05).There were mild adverse reactions in both groups during treatment,which were relieved with symptomatic treatment.There was no statistical significance in the total incidence rate of adverse reactions (P>0.05).Conclusion The application of Zhenwu decoction in treating patients with CPHD can enhance cardiopulmonary function recovery,effectively lower the levels of inflammatory factors,alleviate the clinical symptoms,and demonstrate good safety.
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